Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA041248-11
Application #
2090399
Study Section
Metabolic Pathology Study Section (MEP)
Project Start
1994-09-30
Project End
1998-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
11
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Colorado Denver
Department
Type
Schools of Pharmacy
DUNS #
065391526
City
Aurora
State
CO
Country
United States
Zip Code
80045
Shearn, Colin T; Fritz, Kristofer S; Thompson, John A (2011) Protein damage from electrophiles and oxidants in lungs of mice chronically exposed to the tumor promoter butylated hydroxytoluene. Chem Biol Interact 192:278-86
Shearn, Colin T; Fritz, Kristofer S; Meier, Brent W et al. (2008) Carbonyl reductase inactivation may contribute to mouse lung tumor promotion by electrophilic metabolites of butylated hydroxytoluene: protein alkylation in vivo and in vitro. Chem Res Toxicol 21:1631-41
Meier, Brent W; Gomez, Jose D; Kirichenko, Oleg V et al. (2007) Mechanistic basis for inflammation and tumor promotion in lungs of 2,6-di-tert-butyl-4-methylphenol-treated mice: electrophilic metabolites alkylate and inactivate antioxidant enzymes. Chem Res Toxicol 20:199-207
Meier, Brent W; Gomez, Jose D; Zhou, Angela et al. (2005) Immunochemical and proteomic analysis of covalent adducts formed by quinone methide tumor promoters in mouse lung epithelial cell lines. Chem Res Toxicol 18:1575-85
Lemercier, Jean-Noel; Meier, Brent W; Gomez, Jose D et al. (2004) Inhibition of glutathione S-transferase P1-1 in mouse lung epithelial cells by the tumor promoter 2,6-di-tert-butyl-4-methylene-2,5-cyclohexadienone (BHT-quinone methide): protein adducts investigated by electrospray mass spectrometry. Chem Res Toxicol 17:1675-83
Sun, Yude; Dwyer-Nield, Lori D; Malkinson, Alvin M et al. (2003) Responses of tumorigenic and non-tumorigenic mouse lung epithelial cell lines to electrophilic metabolites of the tumor promoter butylated hydroxytoluene. Chem Biol Interact 145:41-51
Kupfer, Rene; Dwyer-Nield, Lori D; Malkinson, Alvin M et al. (2002) Lung toxicity and tumor promotion by hydroxylated derivatives of 2,6-di-tert-butyl-4-methylphenol (BHT) and 2-tert-butyl-4-methyl-6-iso-propylphenol: correlation with quinone methide reactivity. Chem Res Toxicol 15:1106-12
Kupfer, R; Liu, S Y; Allentoff, A J et al. (2001) Comparisons of hydroperoxide isomerase and monooxygenase activities of cytochrome P450 for conversions of allylic hydroperoxides and alcohols to epoxyalcohols and diols: probing substrate reorientation in the active site. Biochemistry 40:11490-501
Thompson, J A; Carlson, T J; Sun, Y et al. (2001) Studies using structural analogs and inbred strain differences to support a role for quinone methide metabolites of butylated hydroxytoluene (BHT) in mouse lung tumor promotion. Toxicology 160:197-205
Dwyer-Nield, L D; Thompson, J A; Peljak, G et al. (1998) Selective induction of apoptosis in mouse and human lung epithelial cell lines by the tert-butyl hydroxylated metabolite of butylated hydroxytoluene: a proposed role in tumor promotion. Toxicology 130:115-27

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