Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA041323-11S1
Application #
2090426
Study Section
Biophysical Chemistry Study Section (BBCB)
Project Start
1985-12-01
Project End
1998-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
11
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of California San Francisco
Department
Biochemistry
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143

  Publications

Newby, Zachary; Lee, Tom T; Morse, Richard J et al. (2006) The role of protein dynamics in thymidylate synthase catalysis: variants of conserved 2'-deoxyuridine 5'-monophosphate (dUMP)-binding Tyr-261. Biochemistry 45:7415-28
Birdsall, David L; Finer-Moore, Janet; Stroud, Robert M (2003) The only active mutant of thymidylate synthase D169, a residue far from the site of methyl transfer, demonstrates the exquisite nature of enzyme specificity. Protein Eng 16:229-40
Gonzalez-Pacanowska, Dolores; Ruiz-Perez, Luis M; Carreras-Gomez, Maria Angeles et al. (2003) The structural roles of conserved Pro196, Pro197 and His199 in the mechanism of thymidylate synthase. Protein Eng 16:607-14
Stroud, Robert M; Finer-Moore, Janet S (2003) Conformational dynamics along an enzymatic reaction pathway: thymidylate synthase, ""the movie"". Biochemistry 42:239-47
Finer-Moore, Janet S; Santi, Daniel V; Stroud, Robert M (2003) Lessons and conclusions from dissecting the mechanism of a bisubstrate enzyme: thymidylate synthase mutagenesis, function, and structure. Biochemistry 42:248-56
Fritz, Timothy A; Liu, Lu; Finer-Moore, Janet S et al. (2002) Tryptophan 80 and leucine 143 are critical for the hydride transfer step of thymidylate synthase by controlling active site access. Biochemistry 41:7021-9
Morse, R J; Kawase, S; Santi, D V et al. (2000) Energetic contributions of four arginines to phosphate-binding in thymidylate synthase are more than additive and depend on optimization of ""effective charge balance"". Biochemistry 39:1011-20
Kawase, S; Cho, S W; Rozelle, J et al. (2000) Replacement set mutagenesis of the four phosphate-binding arginine residues of thymidylate synthase. Protein Eng 13:557-63
Variath, P; Liu, Y; Lee, T T et al. (2000) Effects of subunit occupancy on partitioning of an intermediate in thymidylate synthase mutants. Biochemistry 39:2429-35
Stout, T J; Tondi, D; Rinaldi, M et al. (1999) Structure-based design of inhibitors specific for bacterial thymidylate synthase. Biochemistry 38:1607-17

Showing the most recent 10 out of 34 publications