Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA041456-11
Application #
2090455
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1986-01-01
Project End
1998-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
11
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02215
Welner, Robert S; Bararia, Deepak; Amabile, Giovanni et al. (2013) C/EBP? is required for development of dendritic cell progenitors. Blood 121:4073-81
Ye, Min; Zhang, Hong; Amabile, Giovanni et al. (2013) C/EBPa controls acquisition and maintenance of adult haematopoietic stem cell quiescence. Nat Cell Biol 15:385-94
Staber, Philipp B; Zhang, Pu; Ye, Min et al. (2013) Sustained PU.1 levels balance cell-cycle regulators to prevent exhaustion of adult hematopoietic stem cells. Mol Cell 49:934-46
Zhang, Yue; Yan, Xiaomei; Sashida, Goro et al. (2012) Stress hematopoiesis reveals abnormal control of self-renewal, lineage bias, and myeloid differentiation in Mll partial tandem duplication (Mll-PTD) hematopoietic stem/progenitor cells. Blood 120:1118-29
Leddin, Mathias; Perrod, Chiara; Hoogenkamp, Maarten et al. (2011) Two distinct auto-regulatory loops operate at the PU.1 locus in B cells and myeloid cells. Blood 117:2827-38
Huang, Gang; Zhao, Xinghui; Wang, Lan et al. (2011) The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations. Blood 118:6544-52
Levantini, Elena; Lee, Sanghoon; Radomska, Hanna S et al. (2011) RUNX1 regulates the CD34 gene in haematopoietic stem cells by mediating interactions with a distal regulatory element. EMBO J 30:4059-70
Aikawa, Yukiko; Katsumoto, Takuo; Zhang, Pu et al. (2010) PU.1-mediated upregulation of CSF1R is crucial for leukemia stem cell potential induced by MOZ-TIF2. Nat Med 16:580-5, 1p following 585
Hoogenkamp, Maarten; Lichtinger, Monika; Krysinska, Hanna et al. (2009) Early chromatin unfolding by RUNX1: a molecular explanation for differential requirements during specification versus maintenance of the hematopoietic gene expression program. Blood 114:299-309
Ueno, S; Tatetsu, H; Hata, H et al. (2009) PU.1 induces apoptosis in myeloma cells through direct transactivation of TRAIL. Oncogene 28:4116-25

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