Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
2R01CA042026-09A4
Application #
2007552
Study Section
Radiation Study Section (RAD)
Project Start
1985-07-01
Project End
2000-01-31
Budget Start
1997-02-19
Budget End
1998-01-31
Support Year
9
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Thomas Jefferson University
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
061197161
City
Philadelphia
State
PA
Country
United States
Zip Code
19107
Wang, Hongyan; Wang, Minli; Wang, Huichen et al. (2005) Complex H2AX phosphorylation patterns by multiple kinases including ATM and DNA-PK in human cells exposed to ionizing radiation and treated with kinase inhibitors. J Cell Physiol 202:492-502
Wang, Huichen; Rosidi, Bustanur; Perrault, Ronel et al. (2005) DNA ligase III as a candidate component of backup pathways of nonhomologous end joining. Cancer Res 65:4020-30
Iliakis, G; Wang, H; Perrault, A R et al. (2004) Mechanisms of DNA double strand break repair and chromosome aberration formation. Cytogenet Genome Res 104:14-20
Perrault, Ronel; Wang, Huichen; Wang, Minli et al. (2004) Backup pathways of NHEJ are suppressed by DNA-PK. J Cell Biochem 92:781-94
Wang, Huichen; Boecker, Wilfried; Wang, Hongyan et al. (2004) Caffeine inhibits homology-directed repair of I-SceI-induced DNA double-strand breaks. Oncogene 23:824-34
Iliakis, George; Wang, Ya; Guan, Jun et al. (2003) DNA damage checkpoint control in cells exposed to ionizing radiation. Oncogene 22:5834-47
Wang, Huichen; Perrault, Ange Ronel; Takeda, Yoshihiko et al. (2003) Biochemical evidence for Ku-independent backup pathways of NHEJ. Nucleic Acids Res 31:5377-88
Wang, Xiang; Khadpe, Jay; Hu, Baocheng et al. (2003) An overactivated ATR/CHK1 pathway is responsible for the prolonged G2 accumulation in irradiated AT cells. J Biol Chem 278:30869-74
Guan, Jun; Stavridi, Elena; Leeper, Dennis B et al. (2002) Effects of hyperthermia on p53 protein expression and activity. J Cell Physiol 190:365-74
Perrault, R; Cheong, N; Wang, H et al. (2001) RPA facilitates rejoining of DNA double-strand breaks in an in vitro assay utilizing genomic DNA as substrate. Int J Radiat Biol 77:593-607

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