Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA042286-06S1
Application #
3183366
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Project Start
1986-04-01
Project End
1993-11-30
Budget Start
1992-03-01
Budget End
1992-11-30
Support Year
6
Fiscal Year
1992
Total Cost
Indirect Cost
Name
University of Arizona
Department
Type
Schools of Medicine
DUNS #
City
Tucson
State
AZ
Country
United States
Zip Code
85721
Lemke, L E; Paine-Murrieta, G D; Taylor, C W et al. (1999) Wortmannin inhibits the growth of mammary tumors despite the existence of a novel wortmannin-insensitive phosphatidylinositol-3-kinase. Cancer Chemother Pharmacol 44:491-7
Qiao, L; Nan, F; Kunkel, M et al. (1998) 3-Deoxy-D-myo-inositol 1-phosphate, 1-phosphonate, and ether lipid analogues as inhibitors of phosphatidylinositol-3-kinase signaling and cancer cell growth. J Med Chem 41:3303-6
Kirkpatrick, D L; Kuperus, M; Dowdeswell, M et al. (1998) Mechanisms of inhibition of the thioredoxin growth factor system by antitumor 2-imidazolyl disulfides. Biochem Pharmacol 55:987-94
Powis, G; Gallegos, A; Abraham, R T et al. (1997) Inhibition of intracellular Ca2+ signalling, cytotoxicity and antitumor activity of the herbicide oryzalin and its analogues. Cancer Chemother Pharmacol 41:22-8
Kunkel, M W; Kirkpatrick, D L; Johnson, J I et al. (1997) Cell line-directed screening assay for inhibitors of thioredoxin reductase signaling as potential anti-cancer drugs. Anticancer Drug Des 12:659-70
Dvorakova, K; Dorr, R T; Gallegos, A et al. (1997) Pharmacokinetic studies of the herbicide and antitumor compound oryzalin in mice. J Chromatogr B Biomed Sci Appl 696:275-81
Brunner, G; Zalkow, L; Burgess, E et al. (1996) Inhibition of glycosylphosphatidylinositol (GPI) phospholipase D by suramin-like compounds. Anticancer Res 16:2513-6
Oblong, J E; Berggren, M; Gasdaska, P Y et al. (1995) Site-directed mutagenesis of Lys36 in human thioredoxin: the highly conserved residue affects reduction rates and growth stimulation but is not essential for the redox protein's biochemical or biological properties. Biochemistry 34:3319-24
Powis, G; Hill, S R; Frew, T J et al. (1995) Inhibitors of phospholipid intracellular signaling as antiproliferative agents. Med Res Rev 15:121-38
Powis, G (1994) Signalling pathways as targets for anticancer drug development. Pharmacol Ther 62:57-95

Showing the most recent 10 out of 53 publications