Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA042361-05
Application #
3183554
Study Section
Experimental Immunology Study Section (EI)
Project Start
1986-05-01
Project End
1991-08-31
Budget Start
1991-04-01
Budget End
1991-08-31
Support Year
5
Fiscal Year
1991
Total Cost
Indirect Cost
Name
University of California Los Angeles
Department
Type
Schools of Medicine
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Wondimu, Assefa; Liu, Yihui; Su, Yan et al. (2014) Gangliosides drive the tumor infiltration and function of myeloid-derived suppressor cells. Cancer Res 74:5449-57
Jales, Alessandra; Falahati, Rustom; Mari, Elisabeth et al. (2011) Ganglioside-exposed dendritic cells inhibit T-cell effector function by promoting regulatory cell activity. Immunology 132:134-43
Liu, Y; Yan, S; Wondimu, A et al. (2010) Ganglioside synthase knockout in oncogene-transformed fibroblasts depletes gangliosides and impairs tumor growth. Oncogene 29:3297-306
Shen, Weiping; Stone, Kelly; Jales, Alessandra et al. (2008) Inhibition of TLR activation and up-regulation of IL-1R-associated kinase-M expression by exogenous gangliosides. J Immunol 180:4425-32
Shen, Weiping; Falahati, Rustom; Stark, Ryan et al. (2005) Modulation of CD4 Th cell differentiation by ganglioside GD1a in vitro. J Immunol 175:4927-34
Hainz, Ursula; Obexer, Petra; Winkler, Christiana et al. (2005) Monocyte-mediated T-cell suppression and augmented monocyte tryptophan catabolism after human hematopoietic stem-cell transplantation. Blood 105:4127-34
Hettmer, Simone; Ladisch, Stephan; Kaucic, Karen (2005) Low complex ganglioside expression characterizes human neuroblastoma cell lines. Cancer Lett 225:141-9
Hettmer, S; McCarter, R; Ladisch, S et al. (2004) Alterations in neuroblastoma ganglioside synthesis by induction of GD1b synthase by retinoic acid. Br J Cancer 91:389-97
Hettmer, Simone; Malott, Carolin; Woods, William et al. (2003) Biological stratification of human neuroblastoma by complex ""B"" pathway ganglioside expression. Cancer Res 63:7270-6
Caldwell, Sheila; Heitger, Andreas; Shen, Weiping et al. (2003) Mechanisms of ganglioside inhibition of APC function. J Immunol 171:1676-83

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