Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA042448-10
Application #
2090735
Study Section
Chemical Pathology Study Section (CPA)
Project Start
1986-04-01
Project End
2000-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Albert Einstein College of Medicine
Department
Biochemistry
Type
Schools of Medicine
DUNS #
009095365
City
Bronx
State
NY
Country
United States
Zip Code
10461
Patskovsky, Yury; Patskovska, Larysa; Almo, Steven C et al. (2006) Transition state model and mechanism of nucleophilic aromatic substitution reactions catalyzed by human glutathione S-transferase M1a-1a. Biochemistry 45:3852-62
Listowsky, I (2005) Proposed intracellular regulatory functions of glutathione transferases by recognition and binding to S-glutathiolated proteins. J Pept Res 65:42-6
Tchaikovskaya, Tatyana; Fraifeld, Vadim; Urphanishvili, Tinatin et al. (2005) Glutathione S-transferase hGSTM3 and ageing-associated neurodegeneration: relationship to Alzheimer's disease. Mech Ageing Dev 126:309-15
Chico, Diane E; Listowsky, Irving (2005) Diverse expression profiles of glutathione-S-transferase subunits in mammalian urinary bladders. Arch Biochem Biophys 435:56-64
Andorfer, John H; Tchaikovskaya, Tatyana; Listowsky, Irving (2004) Selective expression of glutathione S-transferase genes in the murine gastrointestinal tract in response to dietary organosulfur compounds. Carcinogenesis 25:359-67
Cheng, H; Tchaikovskaya, T; Tu, Y S et al. (2001) Rat glutathione S-transferase M4-4: an isoenzyme with unique structural features including a redox-reactive cysteine-115 residue that forms mixed disulphides with glutathione. Biochem J 356:403-14
Patskovsky, Y V; Patskovska, L N; Listowsky, I (2000) The enhanced affinity for thiolate anion and activation of enzyme-bound glutathione is governed by an arginine residue of human Mu class glutathione S-transferases. J Biol Chem 275:3296-304
Patskovsky, Y V; Huang, M Q; Takayama, T et al. (1999) Distinctive structure of the human GSTM3 gene-inverted orientation relative to the mu class glutathione transferase gene cluster. Arch Biochem Biophys 361:85-93
Patskovsky, Y V; Patskovska, L N; Listowsky, I (1999) Functions of His107 in the catalytic mechanism of human glutathione S-transferase hGSTM1a-1a. Biochemistry 38:1193-202
Patskovsky, Y V; Patskovska, L N; Listowsky, I (1999) An asparagine-phenylalanine substitution accounts for catalytic differences between hGSTM3-3 and other human class mu glutathione S-transferases. Biochemistry 38:16187-94

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