Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA042802-10
Application #
2090970
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Project Start
1986-08-01
Project End
1997-01-31
Budget Start
1996-02-01
Budget End
1997-01-31
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
149617367
City
Boston
State
MA
Country
United States
Zip Code
02215
Jain, Salvia; Stroopinsky, Dina; Yin, Li et al. (2015) Mucin 1 is a potential therapeutic target in cutaneous T-cell lymphoma. Blood 126:354-62
Raina, Deepak; Agarwal, Praveen; Lee, James et al. (2015) Characterization of the MUC1-C Cytoplasmic Domain as a Cancer Target. PLoS One 10:e0135156
Yin, Li; Kufe, Turner; Avigan, David et al. (2014) Targeting MUC1-C is synergistic with bortezomib in downregulating TIGAR and inducing ROS-mediated myeloma cell death. Blood 123:2997-3006
Liu, Suiyang; Yin, Li; Stroopinsky, Dina et al. (2014) MUC1-C oncoprotein promotes FLT3 receptor activation in acute myeloid leukemia cells. Blood 123:734-42
Liu, Yan; Marks, Kevin; Cowley, Glenn S et al. (2013) Metabolic and functional genomic studies identify deoxythymidylate kinase as a target in LKB1-mutant lung cancer. Cancer Discov 3:870-9
Stroopinsky, Dina; Rosenblatt, Jacalyn; Ito, Keisuke et al. (2013) MUC1 is a potential target for the treatment of acute myeloid leukemia stem cells. Cancer Res 73:5569-79
Jin, C; Rajabi, H; Rodrigo, C M et al. (2013) Targeting the eIF4A RNA helicase blocks translation of the MUC1-C oncoprotein. Oncogene 32:2179-88
Jin, Caining; Rajabi, Hasan; Pitroda, Sean et al. (2012) Cooperative interaction between the MUC1-C oncoprotein and the Rab31 GTPase in estrogen receptor-positive breast cancer cells. PLoS One 7:e39432
Ahmad, Rehan; Alam, Maroof; Rajabi, Hasan et al. (2012) The MUC1-C oncoprotein binds to the BH3 domain of the pro-apoptotic BAX protein and blocks BAX function. J Biol Chem 287:20866-75
Raina, Deepak; Ahmad, Rehan; Rajabi, Hasan et al. (2012) Targeting cysteine-mediated dimerization of the MUC1-C oncoprotein in human cancer cells. Int J Oncol 40:1643-9

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