Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
7R01CA042857-10
Application #
2633788
Study Section
Metabolic Pathology Study Section (MEP)
Project Start
1986-07-01
Project End
1999-12-31
Budget Start
1997-12-08
Budget End
1997-12-31
Support Year
10
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Type
Schools of Medicine
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Chen, Jian; Zaidi, Sobia; Rao, Shuyun et al. (2018) Analysis of Genomes and Transcriptomes of Hepatocellular Carcinomas Identifies Mutations and Gene Expression Changes in the Transforming Growth Factor-? Pathway. Gastroenterology 154:195-210
Chen, Jian; Shukla, Vivek; Farci, Patrizia et al. (2017) Loss of the transforming growth factor-? effector ?2-Spectrin promotes genomic instability. Hepatology 65:678-693
Shin, Joshua; Mishra, Viveka; Glasgow, Eric et al. (2017) PRAJA is overexpressed in glioblastoma and contributes to neural precursor development. Genes Cancer 8:640-649
Chen, Jian; Raju, Gottumukkala S; Jogunoori, Wilma et al. (2016) Mutational Profiles Reveal an Aberrant TGF-?-CEA Regulated Pathway in Colon Adenomas. PLoS One 11:e0153933
Chen, Jian; Shukla, Vivek; Farci, Patrizia et al. (2016) Loss of the TGF-? Effector ?2SP Promotes Genomic Instability. Hepatology :
Chen, Jian; Herlong, Franklin H; Stroehlein, John R et al. (2016) Mutations of Chromatin Structure Regulating Genes in Human Malignancies. Curr Protein Pept Sci 17:411-37
Chen, Jian; Yao, Zhi-Xing; Chen, Jiun-Sheng et al. (2016) TGF-?/?2-spectrin/CTCF-regulated tumor suppression in human stem cell disorder Beckwith-Wiedemann syndrome. J Clin Invest 126:527-42
Muñoz, Nina M; Katz, Lior H; Shina, Ji-Hyun et al. (2014) Generation of a mouse model of T-cell lymphoma based on chronic LPS challenge and TGF-? signaling disruption. Genes Cancer 5:348-352
Chen, Chia-Lin; Tsukamoto, Hidekazu; Liu, Jian-Chang et al. (2013) Reciprocal regulation by TLR4 and TGF-? in tumor-initiating stem-like cells. J Clin Invest 123:2832-49
Katz, Lior H; Li, Ying; Chen, Jiun-Sheng et al. (2013) Targeting TGF-? signaling in cancer. Expert Opin Ther Targets 17:743-60

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