Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
2R01CA042992-11
Application #
2091052
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Project Start
1986-08-01
Project End
2000-03-31
Budget Start
1996-06-10
Budget End
1997-03-31
Support Year
11
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Texas MD Anderson Cancer Center
Department
Anatomy/Cell Biology
Type
Other Domestic Higher Education
DUNS #
001910777
City
Houston
State
TX
Country
United States
Zip Code
77030
Yang, Yuanzheng; Huang, Gangxiong; Zhou, Zhichao et al. (2018) miR-20a Regulates FAS Expression in Osteosarcoma Cells by Modulating FAS Promoter Activity and Can be Therapeutically Targeted to Inhibit Lung Metastases. Mol Cancer Ther 17:130-139
Guma, Sergei R; Lee, Dean A; Yu, Ling et al. (2014) Natural killer cell therapy and aerosol interleukin-2 for the treatment of osteosarcoma lung metastasis. Pediatr Blood Cancer 61:618-26
Rao-Bindal, Krithi; Rao, Chethan K; Yu, Ling et al. (2013) Expression of c-FLIP in pulmonary metastases in osteosarcoma patients and human xenografts. Pediatr Blood Cancer 60:575-9
Hollomon, Mario G; Gordon, Nancy; Santiago-O'Farrill, Janice M et al. (2013) Knockdown of autophagy-related protein 5, ATG5, decreases oxidative stress and has an opposing effect on camptothecin-induced cytotoxicity in osteosarcoma cells. BMC Cancer 13:500
Rao-Bindal, Krithi; Koshkina, Nadezhda V; Stewart, John et al. (2013) The histone deacetylase inhibitor, MS-275 (entinostat), downregulates c-FLIP, sensitizes osteosarcoma cells to FasL, and induces the regression of osteosarcoma lung metastases. Curr Cancer Drug Targets 13:411-22
Huang, Gangxiong; Yu, Ling; Cooper, Laurence Jn et al. (2012) Genetically modified T cells targeting interleukin-11 receptor ?-chain kill human osteosarcoma cells and induce the regression of established osteosarcoma lung metastases. Cancer Res 72:271-81
Rao-Bindal, K; Zhou, Z; Kleinerman, E S (2012) MS-275 sensitizes osteosarcoma cells to Fas ligand-induced cell death by increasing the localization of Fas in membrane lipid rafts. Cell Death Dis 3:e369
Huang, Gangxiong; Nishimoto, Kazumasa; Zhou, Zhichao et al. (2012) miR-20a encoded by the miR-17-92 cluster increases the metastatic potential of osteosarcoma cells by regulating Fas expression. Cancer Res 72:908-16
Koshkina, Nadezhda V; Rao-Bindal, Krithi; Kleinerman, Eugenie S (2011) Effect of the histone deacetylase inhibitor SNDX-275 on Fas signaling in osteosarcoma cells and the feasibility of its topical application for the treatment of osteosarcoma lung metastases. Cancer 117:3457-67
Rodriguez Jr, Carlos O; Crabbs, Torrie A; Wilson, Dennis W et al. (2010) Aerosol gemcitabine: preclinical safety and in vivo antitumor activity in osteosarcoma-bearing dogs. J Aerosol Med Pulm Drug Deliv 23:197-206

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