Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA043222-03S1
Application #
3185314
Study Section
Mammalian Genetics Study Section (MGN)
Project Start
1986-07-01
Project End
1990-07-31
Budget Start
1989-01-01
Budget End
1990-07-31
Support Year
3
Fiscal Year
1990
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Arlt, Martin F; Glover, Thomas W (2010) Inhibition of topoisomerase I prevents chromosome breakage at common fragile sites. DNA Repair (Amst) 9:678-89
Ragland, Ryan L; Arlt, Martin F; Hughes, Elizabeth D et al. (2009) Mice hypomorphic for Atr have increased DNA damage and abnormal checkpoint response. Mamm Genome 20:375-85
Howlett, Niall G; Harney, Julie A; Rego, Meghan A et al. (2009) Functional interaction between the Fanconi Anemia D2 protein and proliferating cell nuclear antigen (PCNA) via a conserved putative PCNA interaction motif. J Biol Chem 284:28935-42
Arlt, Martin F; Mulle, Jennifer G; Schaibley, Valerie M et al. (2009) Replication stress induces genome-wide copy number changes in human cells that resemble polymorphic and pathogenic variants. Am J Hum Genet 84:339-50
Ragland, Ryan L; Glynn, Michael W; Arlt, Martin F et al. (2008) Stably transfected common fragile site sequences exhibit instability at ectopic sites. Genes Chromosomes Cancer 47:860-72
Durkin, Sandra G; Ragland, Ryan L; Arlt, Martin F et al. (2008) Replication stress induces tumor-like microdeletions in FHIT/FRA3B. Proc Natl Acad Sci U S A 105:246-51
Durkin, Sandra G; Glover, Thomas W (2007) Chromosome fragile sites. Annu Rev Genet 41:169-92
Durkin, S G; Arlt, M F; Howlett, N G et al. (2006) Depletion of CHK1, but not CHK2, induces chromosomal instability and breaks at common fragile sites. Oncogene 25:4381-8
Miller, C T; Lin, L; Casper, A M et al. (2006) Genomic amplification of MET with boundaries within fragile site FRA7G and upregulation of MET pathways in esophageal adenocarcinoma. Oncogene 25:409-18
Glover, Thomas W (2006) Common fragile sites. Cancer Lett 232:4-12

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