BALB/c mice are more susceptible than C57BL/6 mice to radiation-induced instability and it is hypothesized that this difference determines transformation frequency differences in the two mouse strains. Analysis of F1 progeny suggests that the difference in susceptibility for induction of mammary cancer is a heritable trait and Preliminary Data suggests a similar pattern for inheritance of susceptibility to the induction of cytogenetic instability. Experiments are proposed which will: 1) use F1 and F2 progeny of BALB/c and C57BL/6 mice to determine the pattern of inheritance for susceptibility to genetic instability and radiation transformation; 2) use these recombinant inbred strains to examine co-segregation of the loci controlling the phenotypic traits; and 3) map the loci that determine the susceptibility differences. It is hoped that mapping of these loci will ultimately lead to cloning of the involved genes. Identification of such genes should help identify pathways mechanistically involved in the induction of instability and transformation and may be useful in identifying sub-populations of people who are at increased risk for radiation-induced cancer.
| Fabre, Kristin M; Ramaiah, Lila; Dregalla, Ryan C et al. (2011) Murine Prkdc polymorphisms impact DNA-PKcs function. Radiat Res 175:493-500 |
| Williams, Eli S; Klingler, Rebekah; Ponnaiya, Brian et al. (2009) Telomere dysfunction and DNA-PKcs deficiency: characterization and consequence. Cancer Res 69:2100-7 |
| Carsten, Ronald E; Bachand, Annette M; Bailey, Susan M et al. (2008) Resveratrol reduces radiation-induced chromosome aberration frequencies in mouse bone marrow cells. Radiat Res 169:633-8 |
| Hagelstrom, R T; Askin, K F; Williams, A J et al. (2008) DNA-PKcs and ATM influence generation of ionizing radiation-induced bystander signals. Oncogene 27:6761-9 |
| Williams, Eli S; Stap, Jan; Essers, Jeroen et al. (2007) DNA double-strand breaks are not sufficient to initiate recruitment of TRF2. Nat Genet 39:696-8;author reply 698-9 |
| Bailey, Susan M; Murnane, John P (2006) Telomeres, chromosome instability and cancer. Nucleic Acids Res 34:2408-17 |
| Bailey, S M; Goodwin, E H; Cornforth, M N (2004) Strand-specific fluorescence in situ hybridization: the CO-FISH family. Cytogenet Genome Res 107:14-7 |
| Bailey, Susan M; Brenneman, Mark A; Halbrook, James et al. (2004) The kinase activity of DNA-PK is required to protect mammalian telomeres. DNA Repair (Amst) 3:225-33 |
| Bailey, Susan M; Brenneman, Mark A; Goodwin, Edwin H (2004) Frequent recombination in telomeric DNA may extend the proliferative life of telomerase-negative cells. Nucleic Acids Res 32:3743-51 |
| Bailey, Susan M; Cornforth, Michael N; Ullrich, Robert L et al. (2004) Dysfunctional mammalian telomeres join with DNA double-strand breaks. DNA Repair (Amst) 3:349-57 |
Showing the most recent 10 out of 29 publications
