Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA043600-11
Application #
2091209
Study Section
Experimental Virology Study Section (EVR)
Project Start
1986-03-01
Project End
1999-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
11
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Zhang, Hong; Stavnezer, Ed (2009) Ski regulates muscle terminal differentiation by transcriptional activation of Myog in a complex with Six1 and Eya3. J Biol Chem 284:2867-79
Atanasoski, Suzana; Notterpek, Lucia; Lee, Hye-Youn et al. (2004) The protooncogene Ski controls Schwann cell proliferation and myelination. Neuron 43:499-511
Johnson, Michael; Morris, Shannon; Chen, Aiping et al. (2004) Selection of functional mutations in the U5-IR stem and loop regions of the Rous sarcoma virus genome. BMC Biol 2:8
Chen, Dahu; Xu, Weidong; Bales, Elise et al. (2003) SKI activates Wnt/beta-catenin signaling in human melanoma. Cancer Res 63:6626-34
Morris, Shannon; Johnson, Michael; Stavnezer, Ed et al. (2002) Replication of avian sarcoma virus in vivo requires an interaction between the viral RNA and the TpsiC loop of the tRNA(Trp) primer. J Virol 76:7571-7
Xu, W; Angelis, K; Danielpour, D et al. (2000) Ski acts as a co-repressor with Smad2 and Smad3 to regulate the response to type beta transforming growth factor. Proc Natl Acad Sci U S A 97:5924-9
Nicol, R; Zheng, G; Sutrave, P et al. (1999) Association of specific DNA binding and transcriptional repression with the transforming and myogenic activities of c-Ski. Cell Growth Differ 10:243-54
Cohen, S B; Zheng, G; Heyman, H C et al. (1999) Heterodimers of the SnoN and Ski oncoproteins form preferentially over homodimers and are more potent transforming agents. Nucleic Acids Res 27:1006-14
Nicol, R; Stavnezer, E (1998) Transcriptional repression by v-Ski and c-Ski mediated by a specific DNA binding site. J Biol Chem 273:3588-97
Cohen, S B; Nicol, R; Stavnezer, E (1998) A domain necessary for the transforming activity of SnoN is required for specific DNA binding, transcriptional repression and interaction with TAF(II)110. Oncogene 17:2505-13

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