This program is directed towards the development of new synthetic technology and strategies relating to the enediyne anticancer agents calicheamicin gamma1 l and dynemicin A. The developed methodology will be applied to the total synthesis of the natural products themselves and to the design, synthesis and biological evaluation of a number of related model compounds. It is anticipated that the proposed work will have significance in the areas of organic synthesis, biomedical research, and cancer chemotherapy.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA046446-09
Application #
2092145
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Project Start
1989-09-01
Project End
1996-05-31
Budget Start
1995-06-01
Budget End
1996-05-31
Support Year
9
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92037
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