Abstract

The current application proposes to complete the work initiated on this grant, currently in its tenth year of funding, by characterizing the nuclear factor and determining the mechanism of its action and its relationship to TNF with respect to ACC promotor II expression and PAI-1 gene expression. Finally, the investigators intend to overexpress the nuclear factor and use the factor to establish its role in the control of PAI-1 and ACC gene expression in in vitro transcription systems.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA046882-11
Application #
2633803
Study Section
Metabolic Pathology Study Section (MEP)
Program Officer
Mccarthy, Susan A
Project Start
1988-02-01
Project End
1999-12-31
Budget Start
1998-01-01
Budget End
1999-12-31
Support Year
11
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Purdue University
Department
Biochemistry
Type
Schools of Earth Sciences/Natur
DUNS #
072051394
City
West Lafayette
State
IN
Country
United States
Zip Code
47907

  Publications

Lee, J K; Kim, K H (1999) Roles of acetyl-CoA carboxylase beta in muscle cell differentiation and in mitochondrial fatty acid oxidation. Biochem Biophys Res Commun 254:657-60
Zhang, S; Kim, K H (1998) Essential role of acetyl-CoA carboxylase in the glucose-induced insulin secretion in a pancreatic beta-cell line. Cell Signal 10:35-42
Kim, K H (1997) Regulation of mammalian acetyl-coenzyme A carboxylase. Annu Rev Nutr 17:77-99
Furlong, M T; Mahrenholz, A M; Kim, K H et al. (1997) Identification of the major sites of autophosphorylation of the murine protein-tyrosine kinase Syk. Biochim Biophys Acta 1355:177-90
Zhang, Q; Ekhterae, D; Kim, K H (1997) Molecular cloning and characterization of P113, a mouse SNF2/SWI2-related transcription factor. Gene 202:31-7
Kim, K S; Lee, J K; Kim, K H (1997) Differential use of acetyl-CoA carboxylase genes in the control of diverse cellular processes. Biochem Soc Trans 25:1211-5
Zhang, S; Kim, K H (1997) Protein kinase CK2 down-regulates glucose-activated expression of the acetyl-CoA carboxylase gene. Arch Biochem Biophys 338:227-32
Ha, J; Lee, J K; Kim, K S et al. (1996) Cloning of human acetyl-CoA carboxylase-beta and its unique features. Proc Natl Acad Sci U S A 93:11466-70
Widmer, J; Fassihi, K S; Schlichter, S C et al. (1996) Identification of a second human acetyl-CoA carboxylase gene. Biochem J 316 ( Pt 3):915-22
Daniel, S; Kim, K H (1996) Sp1 mediates glucose activation of the acetyl-CoA carboxylase promoter. J Biol Chem 271:1385-92

Showing the most recent 10 out of 26 publications