Concern about the possible association of postmenopausal hormone use with risk of breast cancer has been increased by several recent studies. Little data are available on the long term effects of progestin used in conjunction with estrogen which has become so common in recent years. Moreover, because of the benefits of estrogen for other diseases, it is important to precisely quantify any risk related to breast cancer. We propose to extend our ongoing multicenter, population-based case-control study of breast cancer to evaluate the relationships between postmenopausal hormone use and alcohol consumption. We will specifically assess use of estrogens with progestins, duration and currency of hormone use, and the interrelationships with alcohol intake. We will interview 5,000 women with newly diagnosed breast cancer identified from the tumor registries of Wisconsin, Massachusetts, and New Hampshire, and 5,000 population-based controls drawn from driver's license and medicare lists. The process will be similar to our current study which achieved a response rate of about 90% for cases and controls and enrolled more than the projected number of subjects. By extending our current study now, we can take advantage of an efficient process developed over the past several years and a well trained team. The large sample is required because of the need for precise estimates for what likely will be modest associations and because progestin plus estrogen use of sufficient duration for study is still relatively uncommon. The University of Wisconsin Clinical Cancer Center and the Harvard School of Public Health will continue to coordinate the study and have submitted separate applications with identical research plans.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA047305-06
Application #
3190864
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Project Start
1988-04-15
Project End
1995-12-31
Budget Start
1993-01-01
Budget End
1993-12-31
Support Year
6
Fiscal Year
1993
Total Cost
Indirect Cost
Name
Harvard University
Department
Type
Schools of Public Health
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115
Passarelli, Michael N; Newcomb, Polly A; Hampton, John M et al. (2016) Cigarette Smoking Before and After Breast Cancer Diagnosis: Mortality From Breast Cancer and Smoking-Related Diseases. J Clin Oncol 34:1315-22
Wyszynski, Asaf; Hong, Chi-Chen; Lam, Kristin et al. (2016) An intergenic risk locus containing an enhancer deletion in 2q35 modulates breast cancer risk by deregulating IGFBP5 expression. Hum Mol Genet 25:3863-3876
Schmidt, Marjanka K; Hogervorst, Frans; van Hien, Richard et al. (2016) Age- and Tumor Subtype-Specific Breast Cancer Risk Estimates for CHEK2*1100delC Carriers. J Clin Oncol 34:2750-60
Zeng, Chenjie (see original citation for additional authors) (2016) Identification of independent association signals and putative functional variants for breast cancer risk through fine-scale mapping of the 12p11 locus. Breast Cancer Res 18:64
Mavaddat, Nasim; Pharoah, Paul D P; Michailidou, Kyriaki et al. (2015) Prediction of breast cancer risk based on profiling with common genetic variants. J Natl Cancer Inst 107:
Sprague, Brian L; Gangnon, Ronald E; Hampton, John M et al. (2015) Variation in Breast Cancer-Risk Factor Associations by Method of Detection: Results From a Series of Case-Control Studies. Am J Epidemiol 181:956-69
Trentham-Dietz, Amy; Sprague, Brian L; Hampton, John M et al. (2014) Modification of breast cancer risk according to age and menopausal status: a combined analysis of five population-based case-control studies. Breast Cancer Res Treat 145:165-75
Warren Andersen, Shaneda; Trentham-Dietz, Amy; Gangnon, Ronald E et al. (2014) Breast cancer susceptibility loci in association with age at menarche, age at natural menopause and the reproductive lifespan. Cancer Epidemiol 38:62-5
Nichols, Hazel B; Trentham-Dietz, Amy; Newcomb, Polly A et al. (2013) Pre-diagnosis oophorectomy, estrogen therapy and mortality in a cohort of women diagnosed with breast cancer. Breast Cancer Res 15:R99
Newcomb, Polly A; Kampman, Ellen; Trentham-Dietz, Amy et al. (2013) Alcohol consumption before and after breast cancer diagnosis: associations with survival from breast cancer, cardiovascular disease, and other causes. J Clin Oncol 31:1939-46

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