Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA047723-08
Application #
2092698
Study Section
Metabolic Pathology Study Section (MEP)
Project Start
1988-02-15
Project End
1998-03-31
Budget Start
1996-02-01
Budget End
1998-03-31
Support Year
8
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Lawrence Berkeley National Laboratory
Department
Biology
Type
Organized Research Units
DUNS #
078576738
City
Berkeley
State
CA
Country
United States
Zip Code
94720
Xie, Zhongwen; Zhang, Yangbin; Guliaev, Anton B et al. (2005) The p-benzoquinone DNA adducts derived from benzene are highly mutagenic. DNA Repair (Amst) 4:1399-409
Guliaev, Anton B; Singer, B; Hang, Bo (2004) Chloroethylnitrosourea-derived ethano cytosine and adenine adducts are substrates for Escherichia coli glycosylases excising analogous etheno adducts. DNA Repair (Amst) 3:1311-21
Guliaev, Anton B; Hang, Bo; Singer, B (2004) Structural insights by molecular dynamics simulations into specificity of the major human AP endonuclease toward the benzene-derived DNA adduct, pBQ-C. Nucleic Acids Res 32:2844-52
Hang, Bo; Singer, B (2003) Protein-protein interactions involving DNA glycosylases. Chem Res Toxicol 16:1181-95
Hang, Bo; Chenna, Ahmed; Guliaev, Anton B et al. (2003) Miscoding properties of 1,N6-ethanoadenine, a DNA adduct derived from reaction with the antitumor agent 1,3-bis(2-chloroethyl)-1-nitrosourea. Mutat Res 531:191-203
Singer, B; Medina, Michael; Zhang, Yanbin et al. (2002) 8-(Hydroxymethyl)-3,N(4)-etheno-C, a potential carcinogenic glycidaldehyde product, miscodes in vitro using mammalian DNA polymerases. Biochemistry 41:1778-85
Hang, Bo; Downing, Gary; Guliaev, Anton B et al. (2002) Novel activity of Escherichia coli mismatch uracil-DNA glycosylase (Mug) excising 8-(hydroxymethyl)-3,N4-ethenocytosine, a potential product resulting from glycidaldehyde reaction. Biochemistry 41:2158-65
Guliaev, Anton B; Hang, Bo; Singer, B (2002) Structural insights by molecular dynamics simulations into differential repair efficiency for ethano-A versus etheno-A adducts by the human alkylpurine-DNA N-glycosylase. Nucleic Acids Res 30:3778-87
Sagi, J; Guliaev, A B; Singer, B (2001) 15-mer DNA duplexes containing an abasic site are thermodynamically more stable with adjacent purines than with pyrimidines. Biochemistry 40:3859-68
Sagi, J; Perry, A; Hang, B et al. (2000) Differential destabilization of the DNA oligonucleotide double helix by a T.G mismatch, 3,N(4)-ethenocytosine, 3,N(4)-ethanocytosine, or an 8-(hydroxymethyl)-3,N(4)-ethenocytosine adduct incorporated into the same sequence contexts. Chem Res Toxicol 13:839-45

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