Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA048121-09
Application #
2092929
Study Section
Chemical Pathology Study Section (CPA)
Project Start
1988-07-01
Project End
1998-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
9
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Lankenau Institute for Medical Research
Department
Type
DUNS #
125797084
City
Wynnewood
State
PA
Country
United States
Zip Code
19096
Marano, C W; Garulacan, L A; Laughlin, K V et al. (2000) Plasma concentrations of soluble tumor necrosis factor receptor I and tumor necrosis factor during cardiopulmonary bypass. Ann Thorac Surg 70:1313-8
Clarke, H; Soler, A P; Mullin, J M (2000) Protein kinase C activation leads to dephosphorylation of occludin and tight junction permeability increase in LLC-PK1 epithelial cell sheets. J Cell Sci 113 ( Pt 18):3187-96
Clarke, H; Ginanni, N; Soler, A P et al. (2000) Regulation of protein kinase C-delta and -epsilon isoforms by phorbol ester treatment of LLC-PK1 renal epithelia. Kidney Int 58:1004-15
Clarke, H; Marano, C W; Peralta Soler, A et al. (2000) Modification of tight junction function by protein kinase C isoforms. Adv Drug Deliv Rev 41:283-301
Clarke, H; Ginanni, N; Laughlin, K V et al. (2000) The transient increase of tight junction permeability induced by bryostatin 1 correlates with rapid downregulation of protein kinase C-alpha. Exp Cell Res 261:239-49
Soler, A P; Miller, R D; Laughlin, K V et al. (1999) Increased tight junctional permeability is associated with the development of colon cancer. Carcinogenesis 20:1425-31
Soler, A P; Marano, C W; Bryans, M et al. (1999) Activation of NF-kappaB is necessary for the restoration of the barrier function of an epithelium undergoing TNF-alpha-induced apoptosis. Eur J Cell Biol 78:56-66
Marano, C W; Lewis, S A; Garulacan, L A et al. (1998) Tumor necrosis factor-alpha increases sodium and chloride conductance across the tight junction of CACO-2 BBE, a human intestinal epithelial cell line. J Membr Biol 161:263-74
Mullin, J M; Ginanni, N; Laughlin, K V (1998) Protein kinase C activation increases transepithelial transport of biologically active insulin. Cancer Res 58:1641-5
Simons, R M; Laughlin, K V; Kampherstein, J A et al. (1998) Pentobarbital affects transepithelial electrophysiological parameters regulated by protein kinase C in rat distal colon. Dig Dis Sci 43:632-40

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