Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA048709-09
Application #
2093024
Study Section
Experimental Virology Study Section (EVR)
Project Start
1989-07-01
Project End
1996-06-30
Budget Start
1996-03-01
Budget End
1996-06-30
Support Year
9
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Zhang, Ling; Liu, Meihong; Merling, Randall et al. (2006) Versatile reporter systems show that transactivation by human T-cell leukemia virus type 1 Tax occurs independently of chromatin remodeling factor BRG1. J Virol 80:7459-68
Liu, Baoying; Liang, Min-Hui; Kuo, Yu-liang et al. (2003) Human T-lymphotropic virus type 1 oncoprotein tax promotes unscheduled degradation of Pds1p/securin and Clb2p/cyclin B1 and causes chromosomal instability. Mol Cell Biol 23:5269-81
Fu, De-Xue; Kuo, Yu-Liang; Liu, Bao-Ying et al. (2003) Human T-lymphotropic virus type I tax activates I-kappa B kinase by inhibiting I-kappa B kinase-associated serine/threonine protein phosphatase 2A. J Biol Chem 278:1487-93
Liang, Min-Hui; Geisbert, Thomas; Yao, Yao et al. (2002) Human T-lymphotropic virus type 1 oncoprotein tax promotes S-phase entry but blocks mitosis. J Virol 76:4022-33
Kuo, Y L; Tang, Y; Harrod, R et al. (2000) Kinase-inducible domain-like region of HTLV type 1 tax is important for NF-kappaB activation. AIDS Res Hum Retroviruses 16:1607-12
Nicot, C; Harrod, R (2000) Distinct p300-responsive mechanisms promote caspase-dependent apoptosis by human T-cell lymphotropic virus type 1 Tax protein. Mol Cell Biol 20:8580-9
Harrod, R; Kuo, Y L; Tang, Y et al. (2000) p300 and p300/cAMP-responsive element-binding protein associated factor interact with human T-cell lymphotropic virus type-1 Tax in a multi-histone acetyltransferase/activator-enhancer complex. J Biol Chem 275:11852-7
Tang, Y; Tie, F; Boros, I et al. (1998) An extended alpha-helix and specific amino acid residues opposite the DNA-binding surface of the cAMP response element binding protein basic domain are important for human T cell lymphotropic retrovirus type I Tax binding. J Biol Chem 273:27339-46
Nicot, C; Tie, F; Giam, C Z (1998) Cytoplasmic forms of human T-cell leukemia virus type 1 Tax induce NF-kappaB activation. J Virol 72:6777-84
Harrod, R; Tang, Y; Nicot, C et al. (1998) An exposed KID-like domain in human T-cell lymphotropic virus type 1 Tax is responsible for the recruitment of coactivators CBP/p300. Mol Cell Biol 18:5052-61

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