Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA049498-07
Application #
2093305
Study Section
Radiation Study Section (RAD)
Project Start
1989-05-15
Project End
2000-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Ayene, Iraimoudi S; Koch, Cameron J; Krisch, Robert E (2007) DNA strand breakage by bivalent metal ions and ionizing radiation. Int J Radiat Biol 83:195-210
Biaglow, John E; Ayene, Iraimoudi S; Koch, Cameron J et al. (2003) Radiation response of cells during altered protein thiol redox. Radiat Res 159:484-94
Ayene, Iraimoudi S; Stamato, Thomas D; Mauldin, Stanley K et al. (2002) Mutation in the glucose-6-phosphate dehydrogenase gene leads to inactivation of Ku DNA end binding during oxidative stress. J Biol Chem 277:9929-35
Ayene, I S; Koch, C J; Tuttle, S W et al. (2000) Oxidation of cellular thiols by hydroxyethyldisulphide inhibits DNA double-strand-break rejoining in G6PD deficient mammalian cells. Int J Radiat Biol 76:1523-31
Ayene, I S; Bernhard, E J; McKenna, W G et al. (2000) DNA as an important target in radiation-induced apoptosis of MYC and MYC plus RAS transfected rat embryo fibroblasts. Int J Radiat Biol 76:343-54
Biaglow, J E; Ayene, I S; Koch, C J et al. (2000) G6PD deficient cells and the bioreduction of disulfides: effects of DHEA, GSH depletion and phenylarsine oxide. Biochem Biophys Res Commun 273:846-52
Kachur, A V; Koch, C J; Biaglow, J E (1999) Mechanism of copper-catalyzed autoxidation of cysteine. Free Radic Res 31:23-34
Horan, A D; Giandomenico, A R; Koch, C J (1999) Effect of oxygen on radiation-induced DNA damage in isolated nuclei. Radiat Res 152:144-53
Stevens, C W; Cerniglia, G J; Giandomenico, A R et al. (1998) DNA damaging agents improve stable gene transfer efficiency in mammalian cells. Radiat Oncol Investig 6:1-9
Biaglow, J E; Koch, C J; Tuttle, S W et al. (1998) The measurement of bioreductive capacity of tumor cells using methylene blue. Int J Radiat Oncol Biol Phys 42:769-73

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