Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
2R01CA049917-04A2
Application #
2093515
Study Section
Special Emphasis Panel (ZRG3-PBC (01))
Project Start
1991-09-30
Project End
1998-12-31
Budget Start
1996-03-10
Budget End
1996-12-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Nebraska Medical Center
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Omaha
State
NE
Country
United States
Zip Code
68198
Cavalieri, Ercole L; Rogan, Eleanor G; Li, Kai-Ming et al. (2005) Identification and quantification of the depurinating DNA adducts formed in mouse skin treated with dibenzo[a,l]pyrene (DB[a,l]P) or its metabolites and in rat mammary gland treated with DB[a,l]P. Chem Res Toxicol 18:976-83
Saeed, Muhammad; Gunselman, Sandra J; Higginbotham, Sheila et al. (2005) Formation of the depurinating N3adenine and N7guanine adducts by reaction of DNA with hexestrol-3',4'-quinone or enzyme-activated 3'-hydroxyhexestrol. Implications for a unifying mechanism of tumor initiation by natural and synthetic estrogens. Steroids 70:37-45
Todorovic, Rosa; Devanesan, Prabu; Rogan, Eleanor et al. (2005) Identification and quantification of stable DNA adducts formed from dibenzo[a,l]pyrene or its metabolites in vitro and in mouse skin and rat mammary gland. Chem Res Toxicol 18:984-90
Saeed, Muhammad; Zahid, Muhammad; Gunselman, Sandra J et al. (2005) Slow loss of deoxyribose from the N7deoxyguanosine adducts of estradiol-3,4-quinone and hexestrol-3',4'-quinone. Implications for mutagenic activity. Steroids 70:29-35
Li, Kai-Ming; Todorovic, Rosa; Devanesan, Prabu et al. (2004) Metabolism and DNA binding studies of 4-hydroxyestradiol and estradiol-3,4-quinone in vitro and in female ACI rat mammary gland in vivo. Carcinogenesis 25:289-97
Cavalieri, Ercole; Rogan, Eleanor; Chakravarti, Dhrubajyoti (2004) The role of endogenous catechol quinones in the initiation of cancer and neurodegenerative diseases. Methods Enzymol 382:293-319
Cavalieri, Ercole L; Rogan, Eleanor G (2004) A unifying mechanism in the initiation of cancer and other diseases by catechol quinones. Ann N Y Acad Sci 1028:247-57
Rogan, Eleanor G; Cavalieri, Ercole L (2004) Estrogen metabolites, conjugates, and DNA adducts: possible biomarkers for risk of breast, prostate, and other human cancers. Adv Clin Chem 38:135-49
Rogan, Eleanor G; Badawi, Alaa F; Devanesan, Prabu D et al. (2003) Relative imbalances in estrogen metabolism and conjugation in breast tissue of women with carcinoma: potential biomarkers of susceptibility to cancer. Carcinogenesis 24:697-702
Mulder, Patrick P J; Devanesan, Prabu; van Alem, Kaj et al. (2003) Fluorobenzo[a]pyrenes as probes of the mechanism of cytochrome P450-catalyzed oxygen transfer in aromatic oxygenations. Free Radic Biol Med 34:734-45

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