Abstract

The simian immunodeficiency virus of macaques (SIV), a T-cell tropic lentivirus closely related to the human immunodeficiency viruses (HIV), induces an AIDS-like disease in juvenile rhesus monkeys. This virus and the rhesus monkey will be utilized as an experimental model for the study of AIDs. This model will be employed to: I. Characterize the CD8+ cellular response of the rhesus monkey to SIV. II. Assess the effects of SIV infection on rhesus monkey bone marrow cellular maturation.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
1R01CA050139-01
Application #
3194415
Study Section
(SRC)
Project Start
1989-03-17
Project End
1994-02-28
Budget Start
1989-03-17
Budget End
1990-02-28
Support Year
1
Fiscal Year
1989
Total Cost
Indirect Cost

  Institution

Name
Harvard University
Department
Type
Schools of Medicine
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Subbramanian, Ramu A; Charini, William A; Kuroda, Marcelo J et al. (2006) Expansion after epitope peptide exposure in vitro predicts cytotoxic T lymphocyte epitope dominance hierarchy in lymphocytes of vaccinated mamu-a*01+ rhesus monkeys. AIDS Res Hum Retroviruses 22:445-52
Greenland, John R; Liu, Huining; Berry, David et al. (2005) Beta-amino ester polymers facilitate in vivo DNA transfection and adjuvant plasmid DNA immunization. Mol Ther 12:164-70
Barouch, Dan H; Truitt, Diana M; Letvin, Norman L (2004) Expression kinetics of the interleukin-2/immunoglobulin (IL-2/Ig) plasmid cytokine adjuvant. Vaccine 22:3092-7
Seaman, Michael S; Peyerl, Fred W; Jackson, Shawn S et al. (2004) Subsets of memory cytotoxic T lymphocytes elicited by vaccination influence the efficiency of secondary expansion in vivo. J Virol 78:206-15
McKay, Paul F; Barouch, Dan H; Santra, Sampa et al. (2004) Recruitment of different subsets of antigen-presenting cells selectively modulates DNA vaccine-elicited CD4+ and CD8+ T lymphocyte responses. Eur J Immunol 34:1011-20
Zhang, Lei; Ribeiro, Ruy M; Mascola, John R et al. (2004) Effects of antibody on viral kinetics in simian/human immunodeficiency virus infection: implications for vaccination. J Virol 78:5520-2
McKay, Paul F; Barouch, Dan H; Schmitz, Jorn E et al. (2003) Global dysfunction of CD4 T-lymphocyte cytokine expression in simian-human immunodeficiency virus/SIV-infected monkeys is prevented by vaccination. J Virol 77:4695-702
Barouch, Dan H; Kunstman, Jennifer; Glowczwskie, Jennifer et al. (2003) Viral escape from dominant simian immunodeficiency virus epitope-specific cytotoxic T lymphocytes in DNA-vaccinated rhesus monkeys. J Virol 77:7367-75
Barouch, Dan H; McKay, Paul F; Sumida, Shawn M et al. (2003) Plasmid chemokines and colony-stimulating factors enhance the immunogenicity of DNA priming-viral vector boosting human immunodeficiency virus type 1 vaccines. J Virol 77:8729-35
Baig, Jamal; Levy, Daniel B; McKay, Paul F et al. (2002) Elicitation of simian immunodeficiency virus-specific cytotoxic T lymphocytes in mucosal compartments of rhesus monkeys by systemic vaccination. J Virol 76:11484-90

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