Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
2R01CA050224-04A1
Application #
2093664
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Project Start
1991-09-30
Project End
1998-11-30
Budget Start
1995-12-14
Budget End
1996-11-30
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Dartmouth College
Department
Pharmacology
Type
Schools of Medicine
DUNS #
041027822
City
Hanover
State
NH
Country
United States
Zip Code
03755
Bates, Darcy J P; Danilov, Alexey V; Lowrey, Christopher H et al. (2013) Vinblastine rapidly induces NOXA and acutely sensitizes primary chronic lymphocytic leukemia cells to ABT-737. Mol Cancer Ther 12:1504-14
Albershardt, Tina C; Salerni, Bethany L; Soderquist, Ryan S et al. (2011) Multiple BH3 mimetics antagonize antiapoptotic MCL1 protein by inducing the endoplasmic reticulum stress response and up-regulating BH3-only protein NOXA. J Biol Chem 286:24882-95
Bates, Darcy J P; Salerni, Bethany L; Lowrey, Christopher H et al. (2011) Vinblastine sensitizes leukemia cells to cyclin-dependent kinase inhibitors, inducing acute cell cycle phase-independent apoptosis. Cancer Biol Ther 12:314-25
Salerni, Bethany L; Bates, Darcy J; Albershardt, Tina C et al. (2010) Vinblastine induces acute, cell cycle phase-independent apoptosis in some leukemias and lymphomas and can induce acute apoptosis in others when Mcl-1 is suppressed. Mol Cancer Ther 9:791-802