Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
2R01CA050248-04A2
Application #
2093677
Study Section
Pathology B Study Section (PTHB)
Project Start
1991-09-01
Project End
1999-11-30
Budget Start
1996-02-06
Budget End
1996-11-30
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Children's Hospital of Los Angeles
Department
Type
DUNS #
094878337
City
Los Angeles
State
CA
Country
United States
Zip Code
90027
Zhang, B; Groffen, J; Heisterkamp, N (2007) Increased resistance to a farnesyltransferase inhibitor by N-cadherin expression in Bcr/Abl-P190 lymphoblastic leukemia cells. Leukemia 21:1189-97
Cho, Young Jin; Zhang, Bin; Kaartinen, Vesa et al. (2005) Generation of rac3 null mutant mice: role of Rac3 in Bcr/Abl-caused lymphoblastic leukemia. Mol Cell Biol 25:5777-85
Cho, Young Jin; Hemmeryckx, Bianca; Groffen, John et al. (2005) Interaction of Bcr/Abl with C3G, an exchange factor for the small GTPase Rap1, through the adapter protein Crkl. Biochem Biophys Res Commun 333:1276-83
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Curtis, Christina; Hemmeryckx, Bianca; Haataja, Leena et al. (2004) Scambio, a novel guanine nucleotide exchange factor for Rho. Mol Cancer 3:10
Mishra, Suparna; Reichert, Anja; Cunnick, Jess et al. (2003) Protein kinase CKIIalpha interacts with the Bcr moiety of Bcr/Abl and mediates proliferation of Bcr/Abl-expressing cells. Oncogene 22:8255-62
Kaartinen, Vesa; Nagy, Andre; Gonzalez-Gomez, Ignacio et al. (2002) Vestibular dysgenesis in mice lacking Abr and Bcr Cdc42/RacGAPs. Dev Dyn 223:517-25
Heisterkamp, Nora; Groffen, John (2002) Philadelphia-positive leukemia: a personal perspective. Oncogene 21:8536-40
Hemmeryckx, Bianca; Reichert, Anja; Watanabe, Meguru et al. (2002) BCR/ABL P190 transgenic mice develop leukemia in the absence of Crkl. Oncogene 21:3225-31
Reichert, A; Heisterkamp, N; Daley, G Q et al. (2001) Treatment of Bcr/Abl-positive acute lymphoblastic leukemia in P190 transgenic mice with the farnesyl transferase inhibitor SCH66336. Blood 97:1399-403

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