Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA050376-07
Application #
2093736
Study Section
Special Emphasis Panel (ZRG3-ET-1 (02))
Project Start
1989-09-01
Project End
1999-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Georgetown University
Department
Biochemistry
Type
Schools of Dentistry
DUNS #
049515844
City
Washington
State
DC
Country
United States
Zip Code
20057
Khattar, Vinayak; Thottassery, Jaideep V (2013) Cks1: Structure, Emerging Roles and Implications in Multiple Cancers. J Cancer Ther 4:1341-1354
Westbrook, Louise; Manuvakhova, Marina; Kern, Francis G et al. (2007) Cks1 regulates cdk1 expression: a novel role during mitotic entry in breast cancer cells. Cancer Res 67:11393-401
Manuvakhova, M; Thottassery, J V; Hays, S et al. (2006) Expression of the SNT-1/FRS2 phosphotyrosine binding domain inhibits activation of MAP kinase and PI3-kinase pathways and antiestrogen resistant growth induced by FGF-1 in human breast carcinoma cells. Oncogene 25:6003-14
Estes 2nd, Norman R; Thottassery, Jaideep V; Kern, Francis G (2006) siRNA mediated knockdown of fibroblast growth factor receptors 1 or 3 inhibits FGF-induced anchorage-independent clonogenicity but does not affect MAPK activation. Oncol Rep 15:1407-16
Estes 2nd, Norman R; Thottassery, Jaideep V; Westbrook, Louise et al. (2006) MEK ablation in MCF-7 cells blocks DNA synthesis induced by serum, but not by estradiol or growth factors. Int J Oncol 29:1573-80
Qu, Zhican; Thottassery, Jaideep V; Van Ginkel, Sabrina et al. (2004) Homogeneity and long-term stability of tetracycline-regulated gene expression with low basal activity by using the rtTA2S-M2 transactivator and insulator-flanked reporter vectors. Gene 327:61-73
Thottassery, Jaideep V; Sun, Yanjie; Westbrook, Louise et al. (2004) Prolonged extracellular signal-regulated kinase 1/2 activation during fibroblast growth factor 1- or heregulin beta1-induced antiestrogen-resistant growth of breast cancer cells is resistant to mitogen-activated protein/extracellular regulated kinase kina Cancer Res 64:4637-47
Oh, A S; Lorant, L A; Holloway, J N et al. (2001) Hyperactivation of MAPK induces loss of ERalpha expression in breast cancer cells. Mol Endocrinol 15:1344-59
Zhang, L; Kharbanda, S; McLeskey, S W et al. (1999) Overexpression of fibroblast growth factor 1 in MCF-7 breast cancer cells facilitates tumor cell dissemination but does not support the development of macrometastases in the lungs or lymph nodes. Cancer Res 59:5023-9
Zhang, L; Kharbanda, S; Hanfelt, J et al. (1998) Both autocrine and paracrine effects of transfected acidic fibroblast growth factor are involved in the estrogen-independent and antiestrogen-resistant growth of MCF-7 breast cancer cells. Cancer Res 58:352-61

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