We propose the continued follow-up of a prospective cohort of 116,678 female nurses, aged 25-42 in 1989 (Nurses' Health Study II), to assess specific proposed risk factors for breast cancer, melanoma, and infertility. The five major specific hypotheses we will address are presented as questions to be addressed: 1. Does use of oral contraceptives increase the risk of breast cancer? In particular, does extended use of oral contraceptives before first pregnancy increase this risk? 2. Do higher levels of physical activity, particularly in adolescence and young adulthood, reduce risk of breast cancer? 3. Does alcohol intake in early adulthood increase breast cancer risk, and are higher levels of vitamin A-intake during this period protective? 4. Does use of oral contraceptives increase risk of melanoma? 5. Are extremes of body mass index, smoking, specific dietary factors, increased levels of physical activity, and menstrual characteristics related to risk of infertility? To accomplish this, we will maintain follow-up of the cohort by mailing questionnaires at two-year intervals to update information on exposure status and to ascertain incident cases of non-fatal diagnoses of cancer and other health outcomes, which will be further documented by review of medical records. Follow-up of this cohort to date has been exceptionally high. Deaths among non-respondents will be ascertained by use of the National Death Index. Exposure status for oral contraceptive use and physical activity will be updated by using instruments validated in this cohort. Dietary exposures will be measured using a food frequency questionnaire extensively validated in the original Nurses' Health Study. We will have substantial power to examine the above hypotheses by the end of the fourth cycle of follow-up (in 1998). This study will not only provide essential information for women and their physician making decisions or contraceptive practice, but also serve as a base for examining other etiologies of breast cancer as well as causes of other diseases that affect younger women, such as cardiovascular disease and diabetes.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA050385-10
Application #
2667920
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Program Officer
Patel, Appasaheb1 R
Project Start
1989-07-17
Project End
1999-02-28
Budget Start
1998-05-08
Budget End
1999-02-28
Support Year
10
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Harvard University
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115
Kensler, Kevin H; Beca, Francisco; Baker, Gabrielle M et al. (2018) Androgen receptor expression in normal breast tissue and subsequent breast cancer risk. NPJ Breast Cancer 4:33
Farvid, Maryam S; Chen, Wendy Y; Rosner, Bernard A et al. (2018) Fruit and vegetable consumption and breast cancer incidence: Repeated measures over 30 years of follow-up. Int J Cancer :
Mahalingaiah, S; Missmer, S E; Cheng, J J et al. (2018) Perimenarchal air pollution exposure and menstrual disorders. Hum Reprod 33:512-519
Ding, Ming; Chavarro, Jorge; Olsen, Sjurdur et al. (2018) Genetic variants of gestational diabetes mellitus: a study of 112 SNPs among 8722 women in two independent populations. Diabetologia 61:1758-1768
Farvid, Maryam S; Eliassen, A Heather; Cho, Eunyoung et al. (2018) Dairy Consumption in Adolescence and Early Adulthood and Risk of Breast Cancer. Cancer Epidemiol Biomarkers Prev 27:575-584
Rice, Megan S; Tamimi, Rulla M; Bertrand, Kimberly A et al. (2018) Does mammographic density mediate risk factor associations with breast cancer? An analysis by tumor characteristics. Breast Cancer Res Treat 170:129-141
Bao, Wei; Song, Yiqing; Bertrand, Kimberly A et al. (2018) Prepregnancy habitual intake of vitamin D from diet and supplements in relation to risk of gestational diabetes mellitus: A prospective cohort study. J Diabetes 10:373-379
Heng, Yujing J; Wang, Jun; Ahearn, Thomas U et al. (2018) Molecular mechanisms linking high body mass index to breast cancer etiology in post-menopausal breast tumor and tumor-adjacent tissues. Breast Cancer Res Treat :
Zong, Geng; Valvi, Damaskini; Coull, Brent et al. (2018) Persistent organic pollutants and risk of type 2 diabetes: A prospective investigation among middle-aged women in Nurses' Health Study II. Environ Int 114:334-342
Hirko, Kelly A; Chai, Boyang; Spiegelman, Donna et al. (2018) Erythrocyte membrane fatty acids and breast cancer risk: a prospective analysis in the nurses' health study II. Int J Cancer 142:1116-1129

Showing the most recent 10 out of 585 publications