Abstract

This a revised application in which the contribution of Ras to signaling will be investigated in three different settings: 1. Regulation of PDGFR expression and function. 2. TCR-activated pathways. 3. TCR/Ras-induced programmed cell death.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA050459-08
Application #
2414194
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1990-05-01
Project End
2001-04-30
Budget Start
1997-05-01
Budget End
1998-04-30
Support Year
8
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
Boston University
Department
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118

  Publications

van de Mark, Karyn; Chen, James S; Steliou, Kosta et al. (2003) Alpha-lipoic acid induces p27Kip-dependent cell cycle arrest in non-transformed cell lines and apoptosis in tumor cell lines. J Cell Physiol 194:325-40
Guo, Ning; Faller, Douglas V; Vaziri, Cyrus (2002) Carcinogen-induced S-phase arrest is Chk1 mediated and caffeine sensitive. Cell Growth Differ 13:77-86
Stice, Ligaya L; Forman, Lora W; Hahn, Chang S et al. (2002) Desensitization of the PDGFbeta receptor by modulation of the cytoskeleton: the role of p21(Ras) and Rho family GTPases. Exp Cell Res 275:17-30
Ma, Peihong; Magut, Maureen; Faller, Douglas V et al. (2002) The role of Ras in T lymphocyte activation. Cell Signal 14:849-59
Lynch, E M; Moreland, R B; Ginis, I et al. (2001) Hypoxia-activated ligand HAL-1/13 is lupus autoantigen Ku80 and mediates lymphoid cell adhesion in vitro. Am J Physiol Cell Physiol 280:C897-911
Demary, K; Wong, L; Liou, J S et al. (2001) Redox control of retinoic acid receptor activity: a novel mechanism for retinoic acid resistance in melanoma cells. Endocrinology 142:2600-5
Chen, C Y; Juo, P; Liou, J S et al. (2001) The recruitment of Fas-associated death domain/caspase-8 in Ras-induced apoptosis. Cell Growth Differ 12:297-306
Guo, N; Faller, D V; Denis, G V (2000) Activation-induced nuclear translocation of RING3. J Cell Sci 113 ( Pt 17):3085-91
Ghosh, S K; Roy-Burman, P; Faller, D V (2000) Long terminal repeat regions from exogenous but not endogenous feline leukemia viruses transactivate cellular gene expression. J Virol 74:9742-8
Denis, G V; Vaziri, C; Guo, N et al. (2000) RING3 kinase transactivates promoters of cell cycle regulatory genes through E2F. Cell Growth Differ 11:417-24

Showing the most recent 10 out of 23 publications