Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA050519-02
Application #
3195045
Study Section
Radiation Study Section (RAD)
Project Start
1989-07-01
Project End
1992-06-30
Budget Start
1990-07-01
Budget End
1991-06-30
Support Year
2
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Los Alamos National Lab
Department
Type
Organized Research Units
DUNS #
City
Los Alamos
State
NM
Country
United States
Zip Code
87545
Mori, Eiichiro; Davis, Anthony J; Hasegawa, Masatoshi et al. (2016) Lysines 3241 and 3260 of DNA-PKcs are important for genomic stability and radioresistance. Biochem Biophys Res Commun 477:235-40
Davis, Anthony J; Lee, Kyung-Jong; Chen, David J (2013) The N-terminal region of the DNA-dependent protein kinase catalytic subunit is required for its DNA double-stranded break-mediated activation. J Biol Chem 288:7037-46
Wang, Hailong; Shi, Linda Z; Wong, Catherine C L et al. (2013) The interaction of CtIP and Nbs1 connects CDK and ATM to regulate HR-mediated double-strand break repair. PLoS Genet 9:e1003277
Chung, Young Min; Park, See-Hyoung; Tsai, Wen-Bin et al. (2012) FOXO3 signalling links ATM to the p53 apoptotic pathway following DNA damage. Nat Commun 3:1000
Sun, Jingxin; Lee, Kyung-Jong; Davis, Anthony J et al. (2012) Human Ku70/80 protein blocks exonuclease 1-mediated DNA resection in the presence of human Mre11 or Mre11/Rad50 protein complex. J Biol Chem 287:4936-45
Shao, Zhengping; Davis, Anthony J; Fattah, Kazi R et al. (2012) Persistently bound Ku at DNA ends attenuates DNA end resection and homologous recombination. DNA Repair (Amst) 11:310-6
Pankotai, Tibor; Bonhomme, Celine; Chen, David et al. (2012) DNAPKcs-dependent arrest of RNA polymerase II transcription in the presence of DNA breaks. Nat Struct Mol Biol 19:276-82
Zheng, Junke; Umikawa, Masato; Zhang, Shichuan et al. (2011) Ex vivo expanded hematopoietic stem cells overcome the MHC barrier in allogeneic transplantation. Cell Stem Cell 9:119-30
Zhang, Shichuan; Yajima, Hirohiko; Huynh, Hoangdinh et al. (2011) Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair. J Cell Biol 193:295-305
Castore, Reneau; Hughes, Cameron; Debeaux, Austin et al. (2011) Mycobacterium tuberculosis Ku can bind to nuclear DNA damage and sensitize mammalian cells to bleomycin sulfate. Mutagenesis 26:795-803

Showing the most recent 10 out of 101 publications