Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA052040-05
Application #
2094562
Study Section
Radiation Study Section (RAD)
Project Start
1991-01-01
Project End
1999-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Vermont & St Agric College
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
066811191
City
Burlington
State
VT
Country
United States
Zip Code
05405
Laverty, Daniel J; Averill, April M; Doublié, Sylvie et al. (2017) The A-Rule and Deletion Formation During Abasic and Oxidized Abasic Site Bypass by DNA Polymerase ?. ACS Chem Biol 12:1584-1592
Malaby, Andrew W; Martin, Sara K; Wood, Richard D et al. (2017) Expression and Structural Analyses of Human DNA Polymerase ? (POLQ). Methods Enzymol 592:103-121
Wood, Richard D; Doublié, Sylvie (2016) DNA polymerase ? (POLQ), double-strand break repair, and cancer. DNA Repair (Amst) 44:22-32
Zahn, Karl E; Averill, April M; Aller, Pierre et al. (2015) Human DNA polymerase ? grasps the primer terminus to mediate DNA repair. Nat Struct Mol Biol 22:304-11
Piret, Jocelyne; Goyette, Nathalie; Eckenroth, Brian E et al. (2015) Contrasting effects of W781V and W780V mutations in helix N of herpes simplex virus 1 and human cytomegalovirus DNA polymerases on antiviral drug susceptibility. J Virol 89:4636-44
Lubula, Mulu Y; Eckenroth, Brian E; Carlson, Samuel et al. (2014) Structural insights into recognition of acetylated histone ligands by the BRPF1 bromodomain. FEBS Lett 588:3844-54
Doublié, Sylvie; Zahn, Karl E (2014) Structural insights into eukaryotic DNA replication. Front Microbiol 5:444
Yousefzadeh, Matthew J; Wyatt, David W; Takata, Kei-Ichi et al. (2014) Mechanism of suppression of chromosomal instability by DNA polymerase POLQ. PLoS Genet 10:e1004654
Lubula, Mulu Y; Poplawaski, Amanda; Glass, Karen C (2014) Crystallization and preliminary X-ray diffraction analysis of the BRPF1 bromodomain in complex with its H2AK5ac and H4K12ac histone-peptide ligands. Acta Crystallogr F Struct Biol Commun 70:1389-93
Eckenroth, Brian E; Fleming, Aaron M; Sweasy, Joann B et al. (2014) Crystal structure of DNA polymerase ? with DNA containing the base lesion spiroiminodihydantoin in a templating position. Biochemistry 53:2075-7

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