Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
2R01CA053462-05
Application #
2095340
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1992-08-01
Project End
2001-05-31
Budget Start
1996-08-01
Budget End
1997-05-31
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Virginia
Department
Pathology
Type
Schools of Medicine
DUNS #
001910777
City
Charlottesville
State
VA
Country
United States
Zip Code
22904

  Publications

Arandjelovic, Sanja; Dragojlovic, Nikola; Li, Xiaoqing et al. (2007) A derivative of the plasma protease inhibitor alpha(2)-macroglobulin regulates the response to peripheral nerve injury. J Neurochem 103:694-705
Arandjelovic, Sanja; Van Sant, Cristina L; Gonias, Steven L (2006) Limited mutations in full-length tetrameric human alpha2-macroglobulin abrogate binding of platelet-derived growth factor-BB and transforming growth factor-beta1. J Biol Chem 281:17061-8
Mettenburg, Joseph M; Gonias, Steven L (2005) Beta-amyloid peptide binds equivalently to binary and ternary alpha2-macroglobulin-protease complexes. Protein J 24:89-93
Mettenburg, Joseph M; Arandjelovic, Sanja; Gonias, Steven L (2005) A chemically modified preparation of alpha2-macroglobulin binds beta-amyloid peptide with increased affinity and inhibits Abeta cytotoxicity. J Neurochem 93:53-62
Arandjelovic, Sanja; Hall, Brian D; Gonias, Steven L (2005) Mutation of lysine 1370 in full-length human alpha2-macroglobulin blocks binding to the low density lipoprotein receptor-related protein-1. Arch Biochem Biophys 438:29-35
Gonias, Steven L; Wu, Lihua; Salicioni, Ana Maria (2004) Low density lipoprotein receptor-related protein: regulation of the plasma membrane proteome. Thromb Haemost 91:1056-64
Arandjelovic, Sanja; Freed, Tiffany A; Gonias, Steven L (2003) Growth factor-binding sequence in human alpha2-macroglobulin targets the receptor-binding site in transforming growth factor-beta. Biochemistry 42:6121-7
Hope, Caroline; Mettenburg, Joseph; Gonias, Steven L et al. (2003) Functional analysis of plasma alpha(2)-macroglobulin from Alzheimer's disease patients with the A2M intronic deletion. Neurobiol Dis 14:504-12
Mathew, Smitha; Arandjelovic, Sanja; Beyer, Wayne F et al. (2003) Characterization of the interaction between alpha2-macroglobulin and fibroblast growth factor-2: the role of hydrophobic interactions. Biochem J 374:123-9
Mettenburg, Joseph M; Webb, Donna J; Gonias, Steven L (2002) Distinct binding sites in the structure of alpha 2-macroglobulin mediate the interaction with beta-amyloid peptide and growth factors. J Biol Chem 277:13338-45

Showing the most recent 10 out of 46 publications