Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA053791-02
Application #
3198423
Study Section
Chemical Pathology Study Section (CPA)
Project Start
1991-02-11
Project End
1992-04-30
Budget Start
1992-02-01
Budget End
1992-04-30
Support Year
2
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Lockheed Martin Energy Systems, Inc.
Department
Type
DUNS #
City
Oak Ridge
State
TN
Country
United States
Zip Code
37831
Suganya, Rangaswamy; Chakraborty, Anirban; Miriyala, Sumitra et al. (2015) Suppression of oxidative phosphorylation in mouse embryonic fibroblast cells deficient in apurinic/apyrimidinic endonuclease. DNA Repair (Amst) 27:40-8
Szczesny, Bartosz; Brunyanszki, Attila; Olah, Gabor et al. (2014) Opposing roles of mitochondrial and nuclear PARP1 in the regulation of mitochondrial and nuclear DNA integrity: implications for the regulation of mitochondrial function. Nucleic Acids Res 42:13161-73
Szczesny, Bartosz; Olah, Gabor; Walker, Dillon K et al. (2013) Deficiency in repair of the mitochondrial genome sensitizes proliferating myoblasts to oxidative damage. PLoS One 8:e75201
Tsutakawa, Susan E; Shin, David S; Mol, Clifford D et al. (2013) Conserved structural chemistry for incision activity in structurally non-homologous apurinic/apyrimidinic endonuclease APE1 and endonuclease IV DNA repair enzymes. J Biol Chem 288:8445-55
Sengupta, Shiladitya; Mitra, Sankar; Bhakat, Kishor K (2013) Dual regulatory roles of human AP-endonuclease (APE1/Ref-1) in CDKN1A/p21 expression. PLoS One 8:e68467
Hegde, Muralidhar L; Izumi, Tadahide; Mitra, Sankar (2012) Oxidized base damage and single-strand break repair in mammalian genomes: role of disordered regions and posttranslational modifications in early enzymes. Prog Mol Biol Transl Sci 110:123-53
Hegde, Muralidhar L; Mantha, Anil K; Hazra, Tapas K et al. (2012) Oxidative genome damage and its repair: implications in aging and neurodegenerative diseases. Mech Ageing Dev 133:157-68
Mantha, Anil K; Dhiman, Monisha; Taglialatela, Giulio et al. (2012) Proteomic study of amyloid beta (25-35) peptide exposure to neuronal cells: Impact on APE1/Ref-1's protein-protein interaction. J Neurosci Res 90:1230-9
Sengupta, Shiladitya; Chattopadhyay, Ranajoy; Mantha, Anil K et al. (2012) Regulation of mouse-renin gene by apurinic/apyrimidinic-endonuclease 1 (APE1/Ref-1) via recruitment of histone deacetylase 1 corepressor complex. J Hypertens 30:917-25
Hegde, Muralidhar L; Hegde, Pavana M; Arijit, Dutta et al. (2012) Human DNA Glycosylase NEIL1's Interactions with Downstream Repair Proteins Is Critical for Efficient Repair of Oxidized DNA Base Damage and Enhanced Cell Survival. Biomolecules 2:564-78

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