Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
7R01CA054561-08
Application #
2688589
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Project Start
1991-05-01
Project End
2001-06-30
Budget Start
1997-12-01
Budget End
1998-06-30
Support Year
8
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Corixa Corporation
Department
Type
DUNS #
City
Hamilton
State
WA
Country
United States
Zip Code
Chen, W; Qin, H; Reese, V A et al. (1998) CTLs specific for bcr-abl joining region segment peptides fail to lyse leukemia cells expressing p210 bcr-abl protein. J Immunother 21:257-68
Chen, W; Chatta, G S; Rubin, W D et al. (1998) T cells specific for a polymorphic segment of CD45 induce graft-versus-host disease with predominant pulmonary vasculitis. J Immunol 161:909-18
Disis, M L; Bernhard, H; Shiota, F M et al. (1996) Granulocyte-macrophage colony-stimulating factor: an effective adjuvant for protein and peptide-based vaccines. Blood 88:202-10
Chen, W; Qin, H; Chesebro, B et al. (1996) Identification of a gag-encoded cytotoxic T-lymphocyte epitope from FBL-3 leukemia shared by Friend, Moloney, and Rauscher murine leukemia virus-induced tumors. J Virol 70:7773-82
Disis, M L; Gralow, J R; Bernhard, H et al. (1996) Peptide-based, but not whole protein, vaccines elicit immunity to HER-2/neu, oncogenic self-protein. J Immunol 156:3151-8
Qin, H; Chen, W; Takahashi, M et al. (1995) CD4+ T-cell immunity to mutated ras protein in pancreatic and colon cancer patients. Cancer Res 55:2984-7
Cheever, M A; Disis, M L; Bernhard, H et al. (1995) Immunity to oncogenic proteins. Immunol Rev 145:33-59
Disis, M L; Calenoff, E; McLaughlin, G et al. (1994) Existent T-cell and antibody immunity to HER-2/neu protein in patients with breast cancer. Cancer Res 54:16-20
Peace, D J; Smith, J W; Chen, W et al. (1994) Lysis of ras oncogene-transformed cells by specific cytotoxic T lymphocytes elicited by primary in vitro immunization with mutated ras peptide. J Exp Med 179:473-9
Chen, W; Schweins, E; Chen, X et al. (1994) Retroviral transduction of protein kinase C-gamma into tumor-specific T cells allows antigen-independent long-term growth in IL-2 with retention of functional specificity in vitro and ability to mediate tumor therapy in vivo. J Immunol 153:3630-8

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