Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA055029-06
Application #
2096263
Study Section
Pathology B Study Section (PTHB)
Project Start
1991-09-01
Project End
1999-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Stanford University
Department
Pathology
Type
Schools of Medicine
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305
Yokoyama, Akihiko; Ficara, Francesca; Murphy, Mark J et al. (2011) Proteolytically cleaved MLL subunits are susceptible to distinct degradation pathways. J Cell Sci 124:2208-19
Chang, Pei-Yun; Hom, Robert A; Musselman, Catherine A et al. (2010) Binding of the MLL PHD3 finger to histone H3K4me3 is required for MLL-dependent gene transcription. J Mol Biol 400:137-44
Hom, Robert A; Chang, Pei-Yun; Roy, Siddhartha et al. (2010) Molecular mechanism of MLL PHD3 and RNA recognition by the Cyp33 RRM domain. J Mol Biol 400:145-54
Yokoyama, Akihiko; Lin, Min; Naresh, Alpana et al. (2010) A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription. Cancer Cell 17:198-212
Wong, Piu; Iwasaki, Masayuki; Somervaille, Tim C P et al. (2010) The miR-17-92 microRNA polycistron regulates MLL leukemia stem cell potential by modulating p21 expression. Cancer Res 70:3833-42
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Yokoyama, Akihiko; Cleary, Michael L (2008) Menin critically links MLL proteins with LEDGF on cancer-associated target genes. Cancer Cell 14:36-46
Wang, Zhong; Smith, Kevin S; Murphy, Mark et al. (2008) Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy. Nature 455:1205-9
Wong, Piu; Iwasaki, Masayuki; Somervaille, Tim C P et al. (2007) Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential. Genes Dev 21:2762-74

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