Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
7R01CA056300-07
Application #
2394264
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1991-08-15
Project End
2001-05-31
Budget Start
1996-12-01
Budget End
1997-05-31
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Virginia
Department
Type
Organized Research Units
DUNS #
001910777
City
Charlottesville
State
VA
Country
United States
Zip Code
22904
Joberty, G; Stabila, P F; Coppola, T et al. (1999) High affinity Rab3 binding is dispensable for Rabphilin-dependent potentiation of stimulated secretion. J Cell Sci 112 ( Pt 20):3579-87
Chung, S H; Joberty, G; Gelino, E A et al. (1999) Comparison of the effects on secretion in chromaffin and PC12 cells of Rab3 family members and mutants. Evidence that inhibitory effects are independent of direct interaction with Rabphilin3. J Biol Chem 274:18113-20
Joberty, G; Perlungher, R R; Macara, I G (1999) The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins. Mol Cell Biol 19:6585-97
Neudauer, C L; Joberty, G; Tatsis, N et al. (1998) Distinct cellular effects and interactions of the Rho-family GTPase TC10. Curr Biol 8:1151-60
McKiernan, C J; Stabila, P F; Macara, I G (1996) Role of the Rab3A-binding domain in targeting of rabphilin-3A to vesicle membranes of PC12 cells. Mol Cell Biol 16:4985-95
Darchen, F; Senyshyn, J; Brondyk, W H et al. (1995) The GTPase Rab3a is associated with large dense core vesicles in bovine chromaffin cells and rat PC12 cells. J Cell Sci 108 ( Pt 4):1639-49
Macara, I G; Brondyk, W H (1995) Oligonucleotide mutagenesis of Rab GTPases. Methods Enzymol 257:107-18
Holz, R W; Brondyk, W H; Senter, R A et al. (1994) Evidence for the involvement of Rab3A in Ca(2+)-dependent exocytosis from adrenal chromaffin cells. J Biol Chem 269:10229-34
Brondyk, W H; McKiernan, C J; Burstein, E S et al. (1993) Mutants of Rab3A analogous to oncogenic Ras mutants. Sensitivity to Rab3A-GTPase activating protein and Rab3A-guanine nucleotide releasing factor. J Biol Chem 268:9410-5
Burstein, E S; Brondyk, W H; Macara, I G et al. (1993) Regulation of the GTPase cycle of the neuronally expressed Ras-like GTP-binding protein Rab3A. J Biol Chem 268:22247-50

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