Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA056383-04S1
Application #
2097279
Study Section
Special Emphasis Panel (SRC (40))
Project Start
1992-04-01
Project End
1997-03-31
Budget Start
1995-04-01
Budget End
1997-03-31
Support Year
4
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Kentucky
Department
Pathology
Type
Schools of Medicine
DUNS #
832127323
City
Lexington
State
KY
Country
United States
Zip Code
40506
Connolly, Lanelle; Lasarev, Michael; Jordan, Robert et al. (2006) Atm haploinsufficiency does not affect ionizing radiation mutagenesis in solid mouse tissues. Radiat Res 166:39-46
Wang, Qi; Ponomareva, Olga N; Lasarev, Michael et al. (2006) High frequency induction of mitotic recombination by ionizing radiation in Mlh1 null mouse cells. Mutat Res 594:189-98
Shin-Darlak, Chi Y; Skinner, Amy M; Turker, Mitchell S (2005) A role for Pms2 in the prevention of tandem CC --> TT substitutions induced by ultraviolet radiation and oxidative stress. DNA Repair (Amst) 4:51-7
Turker, Mitchell S; Schwartz, Jeffrey L; Jordan, Robert et al. (2004) Persistence of chromatid aberrations in the cells of solid mouse tissues exposed to 137Cs gamma radiation. Radiat Res 162:357-64
Breger, Kevin S; Smith, Leslie; Turker, Mitchell S et al. (2004) Ionizing radiation induces frequent translocations with delayed replication and condensation. Cancer Res 64:8231-8
Turker, Mitchell S (2003) Autosomal mutation in somatic cells of the mouse. Mutagenesis 18:1-6
Shin, Chi Y; Ponomareva, Olga N; Connolly, Lanelle et al. (2002) A mouse kidney cell line with a G:C --> C:G transversion mutator phenotype. Mutat Res 503:69-76
Shin, Chi Y; Turker, Mitchell S (2002) A:T --> G:C base pair substitutions occur at a higher rate than other substitution events in Pms2 deficient mouse cells. DNA Repair (Amst) 1:995-1001
Ponomareva, Olga N; Rose, Jennifer A; Lasarev, Michael et al. (2002) Tissue-specific deletion and discontinuous loss of heterozygosity are signatures for the mutagenic effects of ionizing radiation in solid tissues. Cancer Res 62:1518-23
Shin, Chi Y; Mellon, Isabel; Turker, Mitchell S (2002) Multiple mutations are common at mouse Aprt in genotoxin-exposed mismatch repair deficient cells. Oncogene 21:1768-76

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