Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
2R01CA056869-04A1
Application #
2097651
Study Section
Physiological Chemistry Study Section (PC)
Project Start
1992-04-01
Project End
1999-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Texas Medical Br Galveston
Department
Type
Organized Research Units
DUNS #
041367053
City
Galveston
State
TX
Country
United States
Zip Code
77555
Fields, Alan P; Murray, Nicole R (2008) Protein kinase C isozymes as therapeutic targets for treatment of human cancers. Adv Enzyme Regul 48:166-78
Ray, Sutapa; Lu, Ying; Kaufmann, Scott H et al. (2004) Genomic mechanisms of p210BCR-ABL signaling: induction of heat shock protein 70 through the GATA response element confers resistance to paclitaxel-induced apoptosis. J Biol Chem 279:35604-15
Yu, Wangsheng; Murray, Nicole R; Weems, Capella et al. (2003) Role of cyclooxygenase 2 in protein kinase C beta II-mediated colon carcinogenesis. J Biol Chem 278:11167-74
Lu, Y; Jamieson, L; Brasier, A R et al. (2001) NF-kappaB/RelA transactivation is required for atypical protein kinase C iota-mediated cell survival. Oncogene 20:4777-92
Denning, G; Jamieson, L; Maquat, L E et al. (2001) Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein. J Biol Chem 276:22709-14
Ray, A; Fields, A P; Ray, B K (2000) Activation of transcription factor SAF involves its phosphorylation by protein kinase C. J Biol Chem 275:39727-33
Li, Q; Subbulakshmi, V; Fields, A P et al. (1999) Protein kinase calpha regulates human monocyte O-2 production and low density lipoprotein lipid oxidation. J Biol Chem 274:3764-71
Jamieson, L; Carpenter, L; Biden, T J et al. (1999) Protein kinase Ciota activity is necessary for Bcr-Abl-mediated resistance to drug-induced apoptosis. J Biol Chem 274:3927-30
Murray, N R; Fields, A P (1998) Phosphatidylglycerol is a physiologic activator of nuclear protein kinase C. J Biol Chem 273:11514-20
Gokmen-Polar, Y; Fields, A P (1998) Mapping of a molecular determinant for protein kinase C betaII isozyme function. J Biol Chem 273:20261-6

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