Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
2R01CA056876-05
Application #
2097659
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1992-04-10
Project End
2001-03-31
Budget Start
1996-06-19
Budget End
1997-03-31
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Pathology
Type
Schools of Medicine
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Pasillas, Martina P; Shah, Meera; Kamps, Mark P (2011) NSD1 PHD domains bind methylated H3K4 and H3K9 using interactions disrupted by point mutations in human sotos syndrome. Hum Mutat 32:292-8
Wang, Gang G; Cai, Ling; Pasillas, Martina P et al. (2007) NUP98-NSD1 links H3K36 methylation to Hox-A gene activation and leukaemogenesis. Nat Cell Biol 9:804-12
Wang, Gang G; Pasillas, Martina P; Kamps, Mark P (2006) Persistent transactivation by meis1 replaces hox function in myeloid leukemogenesis models: evidence for co-occupancy of meis1-pbx and hox-pbx complexes on promoters of leukemia-associated genes. Mol Cell Biol 26:3902-16
Wang, Gang G; Calvo, Katherine R; Pasillas, Martina P et al. (2006) Quantitative production of macrophages or neutrophils ex vivo using conditional Hoxb8. Nat Methods 3:287-93
Wang, Gang G; Pasillas, Martina P; Kamps, Mark P (2005) Meis1 programs transcription of FLT3 and cancer stem cell character, using a mechanism that requires interaction with Pbx and a novel function of the Meis1 C-terminus. Blood 106:254-64
Sykes, David B; Kamps, Mark P (2004) E2a/Pbx1 induces the rapid proliferation of stem cell factor-dependent murine pro-T cells that cause acute T-lymphoid or myeloid leukemias in mice. Mol Cell Biol 24:1256-69
Calvo, Katherine R; Sykes, David B; Pasillas, Martina P et al. (2002) Nup98-HoxA9 immortalizes myeloid progenitors, enforces expression of Hoxa9, Hoxa7 and Meis1, and alters cytokine-specific responses in a manner similar to that induced by retroviral co-expression of Hoxa9 and Meis1. Oncogene 21:4247-56
Calvo, K R; Knoepfler, P S; Sykes, D B et al. (2001) Meis1a suppresses differentiation by G-CSF and promotes proliferation by SCF: potential mechanisms of cooperativity with Hoxa9 in myeloid leukemia. Proc Natl Acad Sci U S A 98:13120-5
Knoepfler, P S; Sykes, D B; Pasillas, M et al. (2001) HoxB8 requires its Pbx-interaction motif to block differentiation of primary myeloid progenitors and of most cell line models of myeloid differentiation. Oncogene 20:5440-8
Sykes, D B; Kamps, M P (2001) Estrogen-dependent E2a/Pbx1 myeloid cell lines exhibit conditional differentiation that can be arrested by other leukemic oncoproteins. Blood 98:2308-18

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