Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA056909-05
Application #
2097680
Study Section
Radiation Study Section (RAD)
Project Start
1991-09-01
Project End
1996-06-30
Budget Start
1995-07-01
Budget End
1996-06-30
Support Year
5
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Sloan-Kettering Institute for Cancer Research
Department
Type
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10065
Sun, Xiaorong; Ackerstaff, Ellen; He, Fuqiu et al. (2015) Visualizing the antivascular effect of bortezomib on the hypoxic tumor microenvironment. Oncotarget 6:34732-44
Hsiao, Hung Tsung; Xing, Ligang; Deng, Xuelong et al. (2014) Hypoxia-targeted triple suicide gene therapy radiosensitizes human colorectal cancer cells. Oncol Rep 32:723-9
Xing, L; Sun, X; Deng, X et al. (2013) A triple suicide gene strategy that improves therapeutic effects and incorporates multimodality molecular imaging for monitoring gene functions. Cancer Gene Ther 20:358-65
Urano, Muneyasu; Li, Gloria C; He, Fuqiu et al. (2012) The effect of DN (dominant-negative) Ku70 and reoxygenation on hypoxia cell-kill: evidence of hypoxia-induced potentially lethal damage. Int J Radiat Biol 88:515-22
Sun, Xiaorong; Xing, Ligang; Deng, Xuelong et al. (2012) Hypoxia targeted bifunctional suicide gene expression enhances radiotherapy in vitro and in vivo. Radiother Oncol 105:57-63
Sun, Xiaorong; Xing, Ligang; Ling, C Clifton et al. (2010) The effect of mild temperature hyperthermia on tumour hypoxia and blood perfusion: relevance for radiotherapy, vascular targeting and imaging. Int J Hyperthermia 26:224-31
Urano, Muneyasu; He, Fuqiu; Minami, Akiko et al. (2010) Response to multiple radiation doses of human colorectal carcinoma cells infected with recombinant adenovirus containing dominant-negative Ku70 fragment. Int J Radiat Oncol Biol Phys 77:877-85
Xing, Ligang; Sun, Xiaorong; Deng, Xuelong et al. (2009) Expression of the bifunctional suicide gene CDUPRT increases radiosensitization and bystander effect of 5-FC in prostate cancer cells. Radiother Oncol 92:345-52
He, Fuqiu; Deng, Xuelong; Wen, Bixiu et al. (2008) Noninvasive molecular imaging of hypoxia in human xenografts: comparing hypoxia-induced gene expression with endogenous and exogenous hypoxia markers. Cancer Res 68:8597-606
Xing, Ligang; Deng, Xuelong; Kotedia, Khushali et al. (2008) Non-invasive molecular and functional imaging of cytosine deaminase and uracil phosphoribosyltransferase fused with red fluorescence protein. Acta Oncol 47:1211-20

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