Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA057307-03S1
Application #
2098046
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Project Start
1994-03-01
Project End
1997-01-31
Budget Start
1996-02-01
Budget End
1997-01-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Sloan-Kettering Institute for Cancer Research
Department
Type
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10065
Huo, Hairong; Magro, Pellegrino G; Pietsch, E Christy et al. (2010) Histone methyltransferase MLL1 regulates MDR1 transcription and chemoresistance. Cancer Res 70:8726-35
Friedman, Debbie; Hu, Zhen; Kolb, E Anders et al. (2002) Ecteinascidin-743 inhibits activated but not constitutive transcription. Cancer Res 62:3377-81
Lin, Y; Ince, T A; Scotto, K W (2001) Optimization of a versatile in vitro transcription assay for the expression of multiple start site TATA-less promoters. Biochemistry 40:12959-66
Johnson, R A; Ince, T A; Scotto, K W (2001) Transcriptional repression by p53 through direct binding to a novel DNA element. J Biol Chem 276:27716-20
Hu, Z; Jin, S; Scotto, K W (2000) Transcriptional activation of the MDR1 gene by UV irradiation. Role of NF-Y and Sp1. J Biol Chem 275:2979-85
Abolhoda, A; Wilson, A E; Ross, H et al. (1999) Rapid activation of MDR1 gene expression in human metastatic sarcoma after in vivo exposure to doxorubicin. Clin Cancer Res 5:3352-6
Jin, S; Scotto, K W (1998) Transcriptional regulation of the MDR1 gene by histone acetyltransferase and deacetylase is mediated by NF-Y. Mol Cell Biol 18:4377-84
Ince, T A; Scotto, K W (1996) Stable transfection of the P-glycoprotein promoter reproduces the endogenous overexpression phenotype: the role of MED-1. Cancer Res 56:2021-4
Ince, T A; Scotto, K W (1995) A conserved downstream element defines a new class of RNA polymerase II promoters. J Biol Chem 270:30249-52