Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
7R01CA057327-05
Application #
2098060
Study Section
Experimental Virology Study Section (EVR)
Project Start
1992-07-16
Project End
1997-04-30
Budget Start
1995-09-01
Budget End
1997-04-30
Support Year
5
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Emory University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
042250712
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Lee, Jocelyn A; Wang, Zhengqi; Sambo, Danielle et al. (2018) Global loss of leucine carboxyl methyltransferase-1 causes severe defects in fetal liver hematopoiesis. J Biol Chem 293:9636-9650
Qadota, Hiroshi; Matsunaga, Yohei; Bagchi, Pritha et al. (2018) Protein phosphatase 2A is crucial for sarcomere organization in Caenorhabditis elegans striated muscle. Mol Biol Cell 29:2084-2097
Hwang, Juyeon; Lee, Jocelyn A; Pallas, David C (2016) Leucine Carboxyl Methyltransferase 1 (LCMT-1) Methylates Protein Phosphatase 4 (PP4) and Protein Phosphatase 6 (PP6) and Differentially Regulates the Stable Formation of Different PP4 Holoenzymes. J Biol Chem 291:21008-21019
Hwang, Juyeon; Pallas, David C (2014) STRIPAK complexes: structure, biological function, and involvement in human diseases. Int J Biochem Cell Biol 47:118-48
Jackson, Jennifer B; Pallas, David C (2012) Circumventing cellular control of PP2A by methylation promotes transformation in an Akt-dependent manner. Neoplasia 14:585-99
Gordon, Johnthan; Hwang, Juyeon; Carrier, Karma J et al. (2011) Protein phosphatase 2a (PP2A) binds within the oligomerization domain of striatin and regulates the phosphorylation and activation of the mammalian Ste20-Like kinase Mst3. BMC Biochem 12:54
Li, Suiyang; Brignole, Claudine; Marcellus, Richard et al. (2009) The adenovirus E4orf4 protein induces G2/M arrest and cell death by blocking protein phosphatase 2A activity regulated by the B55 subunit. J Virol 83:8340-52
Li, Yikun; Wei, Huijun; Hsieh, Tung-Chin et al. (2008) Cdc55p-mediated E4orf4 growth inhibition in Saccharomyces cerevisiae is mediated only in part via the catalytic subunit of protein phosphatase 2A. J Virol 82:3612-23
Lee, Jocelyn A; Pallas, David C (2007) Leucine carboxyl methyltransferase-1 is necessary for normal progression through mitosis in mammalian cells. J Biol Chem 282:30974-84
Narayanan, Usha; Nalavadi, Vijayalaxmi; Nakamoto, Mika et al. (2007) FMRP phosphorylation reveals an immediate-early signaling pathway triggered by group I mGluR and mediated by PP2A. J Neurosci 27:14349-57

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