Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA057569-05
Application #
2098290
Study Section
Radiation Study Section (RAD)
Project Start
1992-07-01
Project End
1997-02-28
Budget Start
1996-03-01
Budget End
1997-02-28
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Benaroya Research Institute at Virginia Mason
Department
Type
DUNS #
City
Seattle
State
WA
Country
United States
Zip Code
98101
Kijas, Amanda W; Lim, Yi Chieh; Bolderson, Emma et al. (2015) ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1. Nucleic Acids Res 43:8352-67
Wen, J; Cerosaletti, K; Schultz, K J et al. (2013) NBN phosphorylation regulates the accumulation of MRN and ATM at sites of DNA double-strand breaks. Oncogene 32:4448-56
Nahas, Shareef A; Davies, Robert; Fike, Francesca et al. (2012) Comprehensive profiling of radiosensitive human cell lines with DNA damage response assays identifies the neutral comet assay as a potential surrogate for clonogenic survival. Radiat Res 177:176-86
Teraoka, Sharon N; Bernstein, Jonine L; Reiner, Anne S et al. (2011) Single nucleotide polymorphisms associated with risk for contralateral breast cancer in the Women's Environment, Cancer, and Radiation Epidemiology (WECARE) Study. Breast Cancer Res 13:R114
Saidi, Amal; Li, Tangliang; Weih, Falk et al. (2010) Dual functions of Nbs1 in the repair of DNA breaks and proliferation ensure proper V(D)J recombination and T-cell development. Mol Cell Biol 30:5572-81
Vissinga, Christine S; Yeo, Tiong C; Warren, Sarah et al. (2009) Nuclear export of NBN is required for normal cellular responses to radiation. Mol Cell Biol 29:1000-6
Demuth, Ilja; Bradshaw, Paul S; Lindner, Anika et al. (2008) Endogenous hSNM1B/Apollo interacts with TRF2 and stimulates ATM in response to ionizing radiation. DNA Repair (Amst) 7:1192-201
Concannon, Patrick; Haile, Robert W; Borresen-Dale, Anne-Lise et al. (2008) Variants in the ATM gene associated with a reduced risk of contralateral breast cancer. Cancer Res 68:6486-91
Cerosaletti, Karen; Wright, Jocyndra; Concannon, Patrick (2006) Active role for nibrin in the kinetics of atm activation. Mol Cell Biol 26:1691-9
Stiff, Thomas; Walker, Sarah A; Cerosaletti, Karen et al. (2006) ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling. EMBO J 25:5775-82

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