Abstract

.) The studies proposed will seek improvement of the immunogenicity of tumor cells by transfection with cDNAs for the recently identified co-stimulatory molecules B7 and the heat-stable antigen (HSA) and test if this approach may lead to the design of better anti-tumor vaccines. It would be determined whether transfection of tumor cells with these cell surface associated co-stimulatory molecules will improve the immunogenicity of tumor cells, whether the transfected tumor cells induce protective anti- tumor immune responses; whether they will induce autoimmunity; whether it is possible to identify tumor specific antigen using tumor cells with improved immunogenicity and if so, whether antigenic TSA peptides induce protective immune responses against the tumor.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA058033-02
Application #
3202333
Study Section
AIDS and Related Research Study Section 4 (ARRD)
Project Start
1992-08-01
Project End
1997-07-31
Budget Start
1993-08-01
Budget End
1994-07-31
Support Year
2
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
New York University
Department
Type
Schools of Medicine
DUNS #
004514360
City
New York
State
NY
Country
United States
Zip Code
10012

  Publications

Liu, Yang (2016) Neoantigen: A Long March toward Cancer Immunotherapy. Clin Cancer Res 22:2602-4
Peng, Gong; Liu, Yang (2015) Hypoxia-inducible factors in cancer stem cells and inflammation. Trends Pharmacol Sci 36:374-83
Wang, Lizhong; Liu, Runhua; Ye, Peiying et al. (2015) Intracellular CD24 disrupts the ARF-NPM interaction and enables mutational and viral oncogene-mediated p53 inactivation. Nat Commun 6:5909
Wang, Yin; Liu, Yan; Tang, Fei et al. (2014) Echinomycin protects mice against relapsed acute myeloid leukemia without adverse effect on hematopoietic stem cells. Blood 124:1127-35
Liu, Yang (2014) A VISTA on PD-1H. J Clin Invest 124:1891-3
Li, Weiquan; Katoh, Hiroto; Wang, Lizhong et al. (2013) FOXP3 regulates sensitivity of cancer cells to irradiation by transcriptional repression of BRCA1. Cancer Res 73:2170-80
Katoh, Hiroto; Zheng, Pan; Liu, Yang (2013) FOXP3: genetic and epigenetic implications for autoimmunity. J Autoimmun 41:72-8
Yang, Yan; Liu, Chengwen; Peng, Weiyi et al. (2012) Antitumor T-cell responses contribute to the effects of dasatinib on c-KIT mutant murine mastocytoma and are potentiated by anti-OX40. Blood 120:4533-43
Tang, Fei; Wu, Qi; Ikenoue, Tsuneo et al. (2012) A critical role for Rictor in T lymphopoiesis. J Immunol 189:1850-7
Wu, Qi; Liu, Yu; Chen, Chong et al. (2011) The tuberous sclerosis complex-mammalian target of rapamycin pathway maintains the quiescence and survival of naive T cells. J Immunol 187:1106-12

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