Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
2R01CA058297-04
Application #
2098992
Study Section
Pathology B Study Section (PTHB)
Project Start
1993-02-01
Project End
2001-02-28
Budget Start
1996-05-01
Budget End
1997-02-28
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
St. Jude Children's Research Hospital
Department
Type
DUNS #
067717892
City
Memphis
State
TN
Country
United States
Zip Code
38105
Iwamoto, Shotaro; Mihara, Keichiro; Downing, James R et al. (2007) Mesenchymal cells regulate the response of acute lymphoblastic leukemia cells to asparaginase. J Clin Invest 117:1049-57
Imai, Chihaya; Iwamoto, Shotaro; Campana, Dario (2005) Genetic modification of primary natural killer cells overcomes inhibitory signals and induces specific killing of leukemic cells. Blood 106:376-83
Imai, C; Campana, D (2004) Genetic modification of T cells for cancer therapy. J Biol Regul Homeost Agents 18:62-71
Imai, C; Mihara, K; Andreansky, M et al. (2004) Chimeric receptors with 4-1BB signaling capacity provoke potent cytotoxicity against acute lymphoblastic leukemia. Leukemia 18:676-84
Mihara, Keichiro; Imai, Chihaya; Coustan-Smith, Elaine et al. (2003) Development and functional characterization of human bone marrow mesenchymal cells immortalized by enforced expression of telomerase. Br J Haematol 120:846-9
Pui, Ching-Hon; Relling, Mary V; Campana, Dario et al. (2002) Childhood acute lymphoblastic leukemia. Rev Clin Exp Hematol 6:161-80; discussion 200-2
Pui, Ching Hon; Relling, Mary V; Evans, William E (2002) Role of pharmacogenomics and pharmacodynamics in the treatment of acute lymphoblastic leukaemia. Best Pract Res Clin Haematol 15:741-56
Suzuki, T; Coustan-Smith, E; Mihara, K et al. (2002) Signals mediated by FcgammaRIIA suppress the growth of B-lineage acute lymphoblastic leukemia cells. Leukemia 16:1276-84
Ito, C; Tecchio, C; Coustan-Smith, E et al. (2002) The antifungal antibiotic clotrimazole alters calcium homeostasis of leukemic lymphoblasts and induces apoptosis. Leukemia 16:1344-52
Srivannaboon, K; Shanafelt, A B; Todisco, E et al. (2001) Interleukin-4 variant (BAY 36-1677) selectively induces apoptosis in acute lymphoblastic leukemia cells. Blood 97:752-8

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