Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA058320-05
Application #
2099025
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1994-05-03
Project End
1997-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Ludwig, Kirsten; Tse, Edison S; Wang, Jean Yj (2013) Colon cancer cells adopt an invasive phenotype without mesenchymal transition in 3-D but not 2-D culture upon combined stimulation with EGF and crypt growth factors. BMC Cancer 13:221
Han, Jinbo; Soletti, Rossana C; Sadarangani, Anil et al. (2013) Nuclear expression of *-catenin promotes RB stability and resistance to TNF-induced apoptosis in colon cancer cells. Mol Cancer Res 11:207-18
Han, Jinbo; Sridevi, Priya; Ramirez, Michael et al. (2013) ýý-Catenin-dependent lysosomal targeting of internalized tumor necrosis factor-ýý suppresses caspase-8 activation in apoptosis-resistant colon cancer cells. Mol Biol Cell 24:465-73
Spehlmann, Martina E; Manthey, Carolin F; Dann, Sara M et al. (2013) Trp53 deficiency protects against acute intestinal inflammation. J Immunol 191:837-47
Bourgo, Ryan J; Thangavel, Chellappagounder; Ertel, Adam et al. (2011) RB restricts DNA damage-initiated tumorigenesis through an LXCXE-dependent mechanism of transcriptional control. Mol Cell 43:663-72
Zeitlin, Samantha G; Chapados, Brian R; Baker, Norman M et al. (2011) Uracil DNA N-glycosylase promotes assembly of human centromere protein A. PLoS One 6:e17151
Knudsen, Erik S; Wang, Jean Y J (2010) Targeting the RB-pathway in cancer therapy. Clin Cancer Res 16:1094-9
Francis, Sarah M; Bergsied, Jacqueline; Isaac, Christian E et al. (2009) A functional connection between pRB and transforming growth factor beta in growth inhibition and mammary gland development. Mol Cell Biol 29:4455-66
Huang, XiaoDong; Masselli, Anja; Frisch, Steven M et al. (2007) Blockade of tumor necrosis factor-induced Bid cleavage by caspase-resistant Rb. J Biol Chem 282:29401-13
Borges, H L; Hunton, I C; Wang, J Y J (2007) Reduction of apoptosis in Rb-deficient embryos via Abl knockout. Oncogene 26:3868-77

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