Abstract

In Specific Aim 1, the PI proposes to test the role of vitronectin's RGD peptide and BD (basic domain) sequences in vitronectin function.
In Specific Aim 2, she proposes to test the role of vitronectin's RG and BD sequence in the fibroblast-mediated endocytosis and degradation of vitronectin.
In Specific Aim 3, she proposes to characterize ligand-binding properties of recombinant vitronectins that are mutated in RGD and/or BD.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA058626-07
Application #
2882390
Study Section
Special Emphasis Panel (ZRG2-MEP (01))
Program Officer
Mohla, Suresh
Project Start
1997-02-01
Project End
2002-02-28
Budget Start
1999-03-01
Budget End
2000-02-29
Support Year
7
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Albany Medical College
Department
Physiology
Type
Schools of Medicine
DUNS #
City
Albany
State
NY
Country
United States
Zip Code
12208

  Publications

Cho, Christina; Horzempa, Carol; Jones, David et al. (2016) The fibronectin III-1 domain activates a PI3-Kinase/Akt signaling pathway leading to ?v?5 integrin activation and TRAIL resistance in human lung cancer cells. BMC Cancer 16:574
Vial, Daniel; McKeown-Longo, Paula J (2016) Role of EGFR expression levels in the regulation of integrin function by EGF. Mol Carcinog 55:1118-23
Cho, Christina; Kelsh-Lasher, Rhiannon; Ambesi, Anthony et al. (2015) Cryptic activity within the Type III1 domain of fibronectin regulates tissue inflammation and angiogenesis. Curr Top Pept Protein Res 16:37-47
Kelsh, Rhiannon M; McKeown-Longo, Paula J; Clark, Richard A F (2015) EDA Fibronectin in Keloids Create a Vicious Cycle of Fibrotic Tumor Formation. J Invest Dermatol 135:1714-1718
Ambesi, Anthony; McKeown-Longo, Paula J (2014) Conformational remodeling of the fibronectin matrix selectively regulates VEGF signaling. J Cell Sci 127:3805-16
Kelsh, Rhiannon; You, Ran; Horzempa, Carol et al. (2014) Regulation of the innate immune response by fibronectin: synergism between the III-1 and EDA domains. PLoS One 9:e102974
Kelsh, Rhiannon M; McKeown-Longo, Paula J (2013) Topographical changes in extracellular matrix: Activation of TLR4 signaling and solid tumor progression. Trends Cancer Res 9:1-13
Vial, Daniel; McKeown-Longo, Paula J (2012) Epidermal growth factor (EGF) regulates ?5?1 integrin activation state in human cancer cell lines through the p90RSK-dependent phosphorylation of filamin A. J Biol Chem 287:40371-80
Ambesi, Anthony; McKeown-Longo, Paula J (2009) Anastellin, the angiostatic fibronectin peptide, is a selective inhibitor of lysophospholipid signaling. Mol Cancer Res 7:255-65
You, Ran; Klein, R Matthew; Zheng, Mingzhe et al. (2009) Regulation of p38 MAP kinase by anastellin is independent of anastellin's effect on matrix fibronectin. Matrix Biol 28:101-9

Showing the most recent 10 out of 20 publications