Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
7R01CA059887-05
Application #
2008257
Study Section
Chemical Pathology Study Section (CPA)
Project Start
1993-05-05
Project End
1998-12-31
Budget Start
1998-03-16
Budget End
1998-12-31
Support Year
5
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
University of Minnesota Twin Cities
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455

  Publications

Peterson, Lisa A (2017) Context Matters: Contribution of Specific DNA Adducts to the Genotoxic Properties of the Tobacco-Specific Nitrosamine NNK. Chem Res Toxicol 30:420-433
Peterson, Lisa A; Urban, Anna M; Vu, Choua C et al. (2013) Role of aldehydes in the toxic and mutagenic effects of nitrosamines. Chem Res Toxicol 26:1464-73
Tubbs, Julie L; Latypov, Vitaly; Kanugula, Sreenivas et al. (2009) Flipping of alkylated DNA damage bridges base and nucleotide excision repair. Nature 459:808-13
Peterson, Lisa A; Wagener, Tanja; Sies, Helmut et al. (2007) Decomposition of S-nitrosocysteine via S- to N-transnitrosation. Chem Res Toxicol 20:721-3
Coulter, Richard; Blandino, Maureen; Tomlinson, Jessica M et al. (2007) Differences in the rate of repair of O6-alkylguanines in different sequence contexts by O6-alkylguanine-DNA alkyltransferase. Chem Res Toxicol 20:1966-71
Mijal, Renee S; Kanugula, Sreenivas; Vu, Choua C et al. (2006) DNA sequence context affects repair of the tobacco-specific adduct O(6)-[4-Oxo-4-(3-pyridyl)butyl]guanine by human O(6)-alkylguanine-DNA alkyltransferases. Cancer Res 66:4968-74
Choi, Jeong-Yun; Chowdhury, Goutam; Zang, Hong et al. (2006) Translesion synthesis across O6-alkylguanine DNA adducts by recombinant human DNA polymerases. J Biol Chem 281:38244-56
Mijal, Renee S; Loktionova, Natalia A; Vu, Choua C et al. (2005) O6-pyridyloxobutylguanine adducts contribute to the mutagenic properties of pyridyloxobutylating agents. Chem Res Toxicol 18:1619-25
Mijal, Renee S; Thomson, Nicole M; Fleischer, Nancy L et al. (2004) The repair of the tobacco specific nitrosamine derived adduct O6-[4-Oxo-4-(3-pyridyl)butyl]guanine by O6-alkylguanine-DNA alkyltransferase variants. Chem Res Toxicol 17:424-34
Thomson, Nicole M; Mijal, Renee S; Ziegel, Rebecca et al. (2004) Development of a quantitative liquid chromatography/electrospray mass spectrometric assay for a mutagenic tobacco specific nitrosamine-derived DNA adduct, O6-[4-Oxo-4-(3-pyridyl)butyl]-2'-deoxyguanosine. Chem Res Toxicol 17:1600-6

Showing the most recent 10 out of 22 publications