Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA060730-03
Application #
2101484
Study Section
Pathology B Study Section (PTHB)
Project Start
1994-01-03
Project End
1998-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Illinois at Chicago
Department
Genetics
Type
Schools of Medicine
DUNS #
121911077
City
Chicago
State
IL
Country
United States
Zip Code
60612
Neznanov, Nickolay; Komarov, Andrei P; Neznanova, Lubov et al. (2011) Proteotoxic stress targeted therapy (PSTT): induction of protein misfolding enhances the antitumor effect of the proteasome inhibitor bortezomib. Oncotarget 2:209-21
Demidenko, Zoya N; Korotchkina, Lioubov G; Gudkov, Andrei V et al. (2010) Paradoxical suppression of cellular senescence by p53. Proc Natl Acad Sci U S A 107:9660-4
Lu, Tao; Jackson, Mark W; Wang, Benlian et al. (2010) Regulation of NF-kappaB by NSD1/FBXL11-dependent reversible lysine methylation of p65. Proc Natl Acad Sci U S A 107:46-51
Neznanov, Nickolay; Gorbachev, Anton V; Neznanova, Lubov et al. (2009) Anti-malaria drug blocks proteotoxic stress response: anti-cancer implications. Cell Cycle 8:3960-70
Lu, Tao; Jackson, Mark W; Singhi, Aatur D et al. (2009) Validation-based insertional mutagenesis identifies lysine demethylase FBXL11 as a negative regulator of NFkappaB. Proc Natl Acad Sci U S A 106:16339-44
Neznanov, Nickolay; Dragunsky, Eugenia M; Chumakov, Konstantin M et al. (2008) Different effect of proteasome inhibition on vesicular stomatitis virus and poliovirus replication. PLoS One 3:e1887
Komarov, Andrei P; Rokhlin, Oskar W; Yu, Chang-An et al. (2008) Functional genetic screening reveals the role of mitochondrial cytochrome b as a mediator of FAS-induced apoptosis. Proc Natl Acad Sci U S A 105:14453-8
Logunov, D Y; Scheblyakov, D V; Zubkova, O V et al. (2008) Mycoplasma infection suppresses p53, activates NF-kappaB and cooperates with oncogenic Ras in rodent fibroblast transformation. Oncogene 27:4521-31
Neznanov, Nickolay; Kondratova, Anna; Chumakov, Konstantin M et al. (2008) Quercetinase pirin makes poliovirus replication resistant to flavonoid quercetin. DNA Cell Biol 27:191-8
Xue, Chengyuan; Haber, Michelle; Flemming, Claudia et al. (2007) p53 determines multidrug sensitivity of childhood neuroblastoma. Cancer Res 67:10351-60

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