Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA061774-03
Application #
2102552
Study Section
Special Emphasis Panel (SRC (70))
Project Start
1994-06-01
Project End
1999-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Georgetown University
Department
Biochemistry
Type
Schools of Dentistry
DUNS #
049515844
City
Washington
State
DC
Country
United States
Zip Code
20057
Yamada, Akimitsu; Nagahashi, Masayuki; Aoyagi, Tomoyoshi et al. (2018) ABCC1-Exported Sphingosine-1-phosphate, Produced by Sphingosine Kinase 1, Shortens Survival of Mice and Patients with Breast Cancer. Mol Cancer Res 16:1059-1070
Aoki, Hiroaki; Aoki, Masayo; Yang, Jing et al. (2016) Murine model of long-term obstructive jaundice. J Surg Res 206:118-125
Aoki, Hiroaki; Aoki, Masayo; Katsuta, Eriko et al. (2016) Host sphingosine kinase 1 worsens pancreatic cancer peritoneal carcinomatosis. J Surg Res 205:510-517
Nagahashi, Masayuki; Yamada, Akimitsu; Miyazaki, Hiroshi et al. (2016) Interstitial Fluid Sphingosine-1-Phosphate in Murine Mammary Gland and Cancer and Human Breast Tissue and Cancer Determined by Novel Methods. J Mammary Gland Biol Neoplasia 21:9-17
Huang, Wei-Ching; Liang, Jie; Nagahashi, Masayuki et al. (2016) Sphingosine-1-phosphate phosphatase 2 promotes disruption of mucosal integrity, and contributes to ulcerative colitis in mice and humans. FASEB J 30:2945-58
Shao, Huanjie; Mohamed, Esraa M; Xu, Guoyan G et al. (2016) Carnitine palmitoyltransferase 1A functions to repress FoxO transcription factors to allow cell cycle progression in ovarian cancer. Oncotarget 7:3832-46
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Nagahashi, Masayuki; Takabe, Kazuaki; Liu, Runping et al. (2015) Conjugated bile acid-activated S1P receptor 2 is a key regulator of sphingosine kinase 2 and hepatic gene expression. Hepatology 61:1216-26
Booth, Laurence; Roberts, Jane L; Tavallai, Mehrad et al. (2015) OSU-03012 and Viagra Treatment Inhibits the Activity of Multiple Chaperone Proteins and Disrupts the Blood-Brain Barrier: Implications for Anti-Cancer Therapies. J Cell Physiol 230:1982-98
Liu, Mingxia; Allegood, Jeremy; Zhu, Xuewei et al. (2015) Uncleaved ApoM signal peptide is required for formation of large ApoM/sphingosine 1-phosphate (S1P)-enriched HDL particles. J Biol Chem 290:7861-70

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