Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA062142-03
Application #
2103176
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1994-01-01
Project End
1996-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Lévay, Magdolna; Settleman, Jeffrey; Ligeti, Erzsébet (2009) Regulation of the substrate preference of p190RhoGAP by protein kinase C-mediated phosphorylation of a phospholipid binding site. Biochemistry 48:8615-23
Jiang, Wei; Betson, Martha; Mulloy, Roseann et al. (2008) p190A RhoGAP is a glycogen synthase kinase-3-beta substrate required for polarized cell migration. J Biol Chem 283:20978-88
Bustos, Rodrigo I; Forget, Marie-Annick; Settleman, Jeffrey E et al. (2008) Coordination of Rho and Rac GTPase function via p190B RhoGAP. Curr Biol 18:1606-11
Chen, Guang-Chao; Lee, Janice Y; Tang, Hong-Wen et al. (2008) Genetic interactions between Drosophila melanogaster Atg1 and paxillin reveal a role for paxillin in autophagosome formation. Autophagy 4:37-45
Betson, Martha; Settleman, Jeffrey (2007) A rho-binding protein kinase C-like activity is required for the function of protein kinase N in Drosophila development. Genetics 176:2201-12
Verdier, Valerie; Johndrow, James E; Betson, Martha et al. (2006) Drosophila Rho-kinase (DRok) is required for tissue morphogenesis in diverse compartments of the egg chamber during oogenesis. Dev Biol 297:417-32
Bradley, William D; Hernandez, Samuel E; Settleman, Jeffrey et al. (2006) Integrin signaling through Arg activates p190RhoGAP by promoting its binding to p120RasGAP and recruitment to the membrane. Mol Biol Cell 17:4827-36
Ligeti, Erzsebet; Settleman, Jeffrey (2006) Regulation of RhoGAP specificity by phospholipids and prenylation. Methods Enzymol 406:104-17
Hakre, Shweta; Tussie-Luna, Maria Isabel; Ashworth, Todd et al. (2006) Opposing functions of TFII-I spliced isoforms in growth factor-induced gene expression. Mol Cell 24:301-8
Matheson, Stephen F; Hu, Kang-Quan; Brouns, Madeleine R et al. (2006) Distinct but overlapping functions for the closely related p190 RhoGAPs in neural development. Dev Neurosci 28:538-50

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