Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
2R01CA063613-05A1
Application #
2744387
Study Section
Special Emphasis Panel (ZRG1-CPA (02))
Program Officer
Marks, Cheryl L
Project Start
1994-06-03
Project End
2003-01-31
Budget Start
1999-04-09
Budget End
2000-01-31
Support Year
5
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Texas MD Anderson Cancer Center
Department
Internal Medicine/Medicine
Type
Organized Research Units
DUNS #
001910777
City
Houston
State
TX
Country
United States
Zip Code
77030
Short, John D; Dere, Ruhee; Houston, Kevin D et al. (2010) AMPK-mediated phosphorylation of murine p27 at T197 promotes binding of 14-3-3 proteins and increases p27 stability. Mol Carcinog 49:429-39
Alexander, Angela; Cai, Sheng-Li; Kim, Jinhee et al. (2010) ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS. Proc Natl Acad Sci U S A 107:4153-8
Alexander, Angela; Kim, Jinhee; Walker, Cheryl L (2010) ATM engages the TSC2/mTORC1 signaling node to regulate autophagy. Autophagy 6:672-3
Kim, Jinhee; Jonasch, Eric; Alexander, Angela et al. (2009) Cytoplasmic sequestration of p27 via AKT phosphorylation in renal cell carcinoma. Clin Cancer Res 15:81-90
Short, John D; Houston, Kevin D; Dere, Ruhee et al. (2008) AMP-activated protein kinase signaling results in cytoplasmic sequestration of p27. Cancer Res 68:6496-506
Lu, Karen H; Wu, Weiguo; Dave, Bhuvanesh et al. (2008) Loss of tuberous sclerosis complex-2 function and activation of mammalian target of rapamycin signaling in endometrial carcinoma. Clin Cancer Res 14:2543-50
Woodruff, Teresa K; Walker, Cheryl Lyn (2008) Fetal and early postnatal environmental exposures and reproductive health effects in the female. Fertil Steril 89:e47-51
Hall, William C; Elder, Bruce; Walker, Cheryl Lyn et al. (2007) Spontaneous renal tubular hyperplastic and neoplastic lesions in three Sprague-Dawley rats from a 90-day toxicity study. Toxicol Pathol 35:233-41
Liang, Jiyong; Shao, Shan H; Xu, Zhi-Xiang et al. (2007) The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis. Nat Cell Biol 9:218-24
Cai, Sheng-Li; Tee, Andrew R; Short, John D et al. (2006) Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning. J Cell Biol 173:279-89

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